Difference between revisions of "Methotrexate (MTX)"
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*[[Penile cancer]] | *[[Penile cancer]] | ||
*[[Peripheral T-cell lymphoma]] | *[[Peripheral T-cell lymphoma]] | ||
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*[[T-cell acute lymphoblastic leukemia]] | *[[T-cell acute lymphoblastic leukemia]] | ||
</div> | </div> | ||
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| + | ==Diseases for which it was used== | ||
| + | *[[Colon cancer - historical|Colon cancer]] | ||
| + | *[[Follicular lymphoma - historical|Follicular lymphoma]] | ||
| + | *[[Gastric cancer - historical|Gastric cancer]] | ||
| + | *[[Hodgkin lymphoma - historical|Hodgkin lymphoma]] | ||
| + | *[[Non-small cell lung cancer - historical|Non-small cell lung cancer]] | ||
| + | *[[Ovarian cancer - historical|Ovarian cancer]] | ||
| + | *[[Prostate cancer - historical|Prostate cancer]] | ||
| + | *[[Small cell lung cancer - historical|Small cell lung cancer]] | ||
==Patient drug information== | ==Patient drug information== | ||
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[[Category:Penile cancer medications]] | [[Category:Penile cancer medications]] | ||
[[Category:Peripheral T-cell lymphoma medications]] | [[Category:Peripheral T-cell lymphoma medications]] | ||
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[[Category:T-cell acute lymphoblastic leukemia medications]] | [[Category:T-cell acute lymphoblastic leukemia medications]] | ||
| + | |||
| + | [[Category:Colon cancer medications (historic)]] | ||
| + | [[Category:Follicular lymphoma medications (historic)]] | ||
| + | [[Category:Gastric cancer medications (historic)]] | ||
| + | [[Category:Hodgkin lymphoma medications (historic)]] | ||
| + | [[Category:Non-small cell lung cancer medications (historic)]] | ||
| + | [[Category:Ovarian cancer medications (historic)]] | ||
| + | [[Category:Prostate cancer medications (historic)]] | ||
| + | [[Category:Small cell lung cancer medications (historic)]] | ||
[[Category:FDA approved in 1953]] | [[Category:FDA approved in 1953]] | ||
[[Category:WHO Essential Cancer Medicine]] | [[Category:WHO Essential Cancer Medicine]] | ||
Revision as of 13:27, 28 April 2022
General information
Class/mechanism: Folate analog, antimetabolite, interferes with DNA synthesis. Methotrexate inhibits dihydrofolic acid reductase, which catalyzes reactions that produce tetrahydrofolates, which are used in purine nucleotide and thymidylate synthesis.[1][2][3][4][5][6][7]
Route: IV, PO, IM, IT, SC, intraarterial
Extravasation: inflammitant
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]
Toxicity
Monitoring of plasma levels
- Stoller RG, Hande KR, Jacobs SA, Rosenberg SA, Chabner BA. Use of plasma pharmacokinetics to predict and prevent methotrexate toxicity. N Engl J Med. 1977 Sep 22;297(12):630-4. link to original article PubMed
Reversal agents
- Glucarpidase (Voraxaze) can be used to treat toxic plasma methotrexate concentrations (greater than 1 micromole per liter) in patients with delayed methotrexate clearance due to impaired renal function
Diseases for which it is used
- Acute promyelocytic leukemia
- Adult T-cell leukemia-lymphoma
- B-cell acute lymphoblastic leukemia
- Bladder cancer
- Breast cancer
- Burkitt lymphoma
- CNS leukemia
- CNS lymphoma
- Cutaneous T-cell lymphoma
- Desmoid tumors
- Diffuse large B-cell lymphoma
- Extranodal NK- and T-cell lymphoma, nasal type
- Gestational trophoblastic neoplasia
- Head and neck cancer
- Hemophagocytic lymphohistiocytosis
- HIV-associated lymphoma
- Langerhans cell histiocytosis
- Large granular lymphocytic leukemia
- Mantle cell lymphoma
- Medulloblastoma
- NK- and T-cell lymphoma
- Osteosarcoma
- Penile cancer
- Peripheral T-cell lymphoma
- T-cell acute lymphoblastic leukemia
Diseases for which it was used
- Colon cancer
- Follicular lymphoma
- Gastric cancer
- Hodgkin lymphoma
- Non-small cell lung cancer
- Ovarian cancer
- Prostate cancer
- Small cell lung cancer
Patient drug information
- Methotrexate (Otrexup) subcutaneous injection package insert[5]
- Methotrexate (MTX) patient drug information (Chemocare)[8]
- Methotrexate (MTX) patient drug information (UpToDate)[9]
History of changes in FDA indication
- 12/7/1953: Initial FDA approval
- Most recent package insert:
- Methotrexate is indicated in the treatment of gestational choriocarcinoma, chorioadenoma destruens and hydatidiform mole.
- In acute lymphocytic leukemia, methotrexate is indicated in the prophylaxis of meningeal leukemia and is used in maintenance therapy in combination with other chemotherapeutic agents.
- Methotrexate is also indicated in the treatment of meningeal leukemia.
- Methotrexate is used alone or in combination with other anticancer agents in the treatment of breast cancer, epidermoid cancers of the head and neck, advanced mycosis fungoides (cutaneous T cell lymphoma), and lung cancer, particularly squamous cell and small cell types.
- Methotrexate is also used in combination with other chemotherapeutic agents in the treatment of advanced stage non-Hodgkin’s lymphomas.
- Methotrexate in high doses followed by leucovorin rescue in combination with other chemotherapeutic agents is effective in prolonging relapse-free survival in patients with non- metastatic osteosarcoma who have undergone surgical resection or amputation for the primary tumor.
Also known as
- Generic names: amethopterin, MTX
- Brand names:
| Synonyms | |||||||
|---|---|---|---|---|---|---|---|
| Abitrexate | Alltrex | Antifolan | Artrait | Biometrox | Biotrexate | Caditrex | Cytotrexate |
| Ebetrexat | Emthexat | Emthexate | Ervemin | Farmitrexat | Fauldmetro | Folex PFS | Folitrax |
| Hextrate | Ifamet | Imutrex | Ledertrexate | Ledertrexato | Lumexon | Matrex | Maxtrex |
| Medsatrexate | Merex | Metex | Methobax | Methoblastin | Methorex | Methotrexaat | Methotrexat |
| Methotrexato | Methotrexatum | Meticil | Metolate | Metotressato | Metotrexate | Metotrexato | Metotrexol |
| Metrex | Metrexan | Metrexato | Metrotex | Mexate | Miantrex CS | Neometho | Neotrexate |
| Novatrex | Oncotrex | O Trexat | Pharmatrexate | Remtrex | Reumatrex | Rextop | Rheumatrex |
| Tecnomet | Texate | Texorate | Tratoben | Tremetex | Trexall | Trexan | Trexeron |
| Trixilem | Unitrexate | Zexate | |||||
References
- ↑ 1.0 1.1 Methotrexate (MTX) tablet package insert
- ↑ Methotrexate (MTX) tablet package insert (locally hosted backup)
- ↑ Methotrexate (MTX) injection package insert
- ↑ Methotrexate (MTX) injection package insert (locally hosted backup)
- ↑ 5.0 5.1 Methotrexate (Otrexup) subcutaneous injection package insert
- ↑ Methotrexate (Otrexup) subcutaneous injection package insert (locally hosted backup)
- ↑ Otrexup manufacturer's website
- ↑ Methotrexate (MTX) patient drug information (Chemocare)
- ↑ Methotrexate (MTX) patient drug information (UpToDate)
Categories:
- Drugs
- Intramuscular medications
- Intrathecal medications
- Intravenous medications
- Oral medications
- Subcutaneous medications
- Inflammitant
- Antimetabolites
- Antifolates
- Immunosuppressants
- Acute promyelocytic leukemia medications
- Adult T-cell leukemia-lymphoma medications
- B-cell acute lymphoblastic leukemia medications
- Bladder cancer medications
- Breast cancer medications
- Burkitt lymphoma medications
- CNS lymphoma medications
- CNS leukemia medications
- Cutaneous T-cell lymphoma medications
- Desmoid tumor medications
- Diffuse large B-cell lymphoma medications
- Extranodal NK- and T-cell lymphoma, nasal type medications
- Gestational trophoblastic neoplasia medications
- Head and neck cancer medications
- Hemophagocytic lymphohistiocytosis medications
- HIV-associated lymphoma medications
- Langerhans cell histiocytosis medications
- Large granular lymphocytic leukemia medications
- Mantle cell lymphoma medications
- Medulloblastoma medications
- NK- and T-cell lymphoma medications
- Osteosarcoma medications
- Penile cancer medications
- Peripheral T-cell lymphoma medications
- T-cell acute lymphoblastic leukemia medications
- Colon cancer medications (historic)
- Follicular lymphoma medications (historic)
- Gastric cancer medications (historic)
- Hodgkin lymphoma medications (historic)
- Non-small cell lung cancer medications (historic)
- Ovarian cancer medications (historic)
- Prostate cancer medications (historic)
- Small cell lung cancer medications (historic)
- FDA approved in 1953
- WHO Essential Cancer Medicine