Difference between revisions of "Fludarabine (Fludara)"
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Warner-admin (talk | contribs) m (Text replacement - "Category:DNA synthesis inhibitors" to "Category:Human DNA synthesis inhibitors") |
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==General information== | ==General information== | ||
| − | Class/mechanism: Purine analog, antimetabolite; fludarabine is converted to the active compound, 2-fluoro-ara-ATP, which inhibits DNA synthesis by inhibiting DNA polymerase alpha, ribonucleotide reductase, and DNA primase. Relatively resistant to deamination by adenosine deaminase. The mechanism of action is not completely characterized and may be multi-faceted.<ref name="insert">[ | + | Class/mechanism: Purine analog, antimetabolite; fludarabine is converted to the active compound, 2-fluoro-ara-ATP, which inhibits DNA synthesis by inhibiting DNA polymerase alpha, ribonucleotide reductase, and DNA primase. Relatively resistant to deamination by adenosine deaminase. The mechanism of action is not completely characterized and may be multi-faceted.<ref name="insert">[https://www.accessdata.fda.gov/drugsatfda_docs/label/2009/020038s032lbl.pdf Fludarabine (Fludara) package insert]</ref><ref>[[Media:Fludarabine.pdf | Fludarabine (Fludara) package insert (locally hosted backup)]]</ref> |
<br>Route: IV, PO ''Note: Oral fludarabine is no longer available in the US, at this time.'' | <br>Route: IV, PO ''Note: Oral fludarabine is no longer available in the US, at this time.'' | ||
<br>Extravasation: [[neutral]] | <br>Extravasation: [[neutral]] | ||
| Line 23: | Line 23: | ||
==Patient drug information== | ==Patient drug information== | ||
| + | *[https://www.accessdata.fda.gov/drugsatfda_docs/label/2009/020038s032lbl.pdf Fludarabine (Fludara) package insert]<ref name="insert"></ref> | ||
*[http://chemocare.com/chemotherapy/drug-info/fludarabine.aspx Fludarabine (Fludara) patient drug information (Chemocare)]<ref>[http://chemocare.com/chemotherapy/drug-info/fludarabine.aspx Fludarabine (Fludara) patient drug information (Chemocare)]</ref> | *[http://chemocare.com/chemotherapy/drug-info/fludarabine.aspx Fludarabine (Fludara) patient drug information (Chemocare)]<ref>[http://chemocare.com/chemotherapy/drug-info/fludarabine.aspx Fludarabine (Fludara) patient drug information (Chemocare)]</ref> | ||
*[http://www.uptodate.com/contents/fludarabine-patient-drug-information Fludarabine (Fludara) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/fludarabine-patient-drug-information Fludarabine (Fludara) patient drug information (UpToDate)]</ref> | *[http://www.uptodate.com/contents/fludarabine-patient-drug-information Fludarabine (Fludara) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/fludarabine-patient-drug-information Fludarabine (Fludara) patient drug information (UpToDate)]</ref> | ||
Revision as of 11:05, 4 April 2021
General information
Class/mechanism: Purine analog, antimetabolite; fludarabine is converted to the active compound, 2-fluoro-ara-ATP, which inhibits DNA synthesis by inhibiting DNA polymerase alpha, ribonucleotide reductase, and DNA primase. Relatively resistant to deamination by adenosine deaminase. The mechanism of action is not completely characterized and may be multi-faceted.[1][2]
Route: IV, PO Note: Oral fludarabine is no longer available in the US, at this time.
Extravasation: neutral
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]
Diseases for which it is used
- Acute myeloid leukemia
- B-cell acute lymphoblastic leukemia
- Chronic lymphocytic leukemia
- Cold agglutinin disease
- Follicular lymphoma
- Hodgkin lymphoma
- Mantle cell lymphoma
- Marginal zone lymphoma
- Peripheral T-cell lymphoma
- Transformed lymphoma
- Waldenström macroglobulinemia
Diseases for which it was used
Patient drug information
- Fludarabine (Fludara) package insert[1]
- Fludarabine (Fludara) patient drug information (Chemocare)[3]
- Fludarabine (Fludara) patient drug information (UpToDate)[4]
History of changes in FDA indication
- 4/18/1991: Initial FDA approval for the treatment of patients with B-cell chronic lymphocytic leukemia (CLL) who have not responded to or whose disease has progressed during treatment with at least one standard alkylating-agent containing regimen.
Also known as
- Generic names: FAMP, fludarabine phosphate
- Brand names: Beneflur, Fludabine, Fludara, Lymfuda, Oforta
References
Categories:
- Drugs
- Intravenous medications
- Oral medications
- Neutral
- Human DNA synthesis inhibitors
- Antimetabolites
- Purine analogues
- Acute myeloid leukemia medications
- B-cell acute lymphoblastic leukemia medications
- Chronic lymphocytic leukemia medications
- Cold agglutinin disease medications
- Follicular lymphoma medications
- Hodgkin lymphoma medications
- Mantle cell lymphoma medications
- Marginal zone lymphoma medications
- Peripheral T-cell lymphoma medications
- Transformed lymphoma medications
- Waldenström macroglobulinemia medications
- FDA approved in 1991
- WHO Essential Cancer Medicine