Difference between revisions of "Rosai-Dorfman-Destombes disease"
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==Consensus guidelines== | ==Consensus guidelines== | ||
*'''2018:''' Abla et al. [http://www.bloodjournal.org/content/131/26/2877.long Consensus recommendations for the diagnosis and clinical management of Rosai-Dorfman-Destombes disease] [https://www.ncbi.nlm.nih.gov/pubmed/29720485 PubMed] | *'''2018:''' Abla et al. [http://www.bloodjournal.org/content/131/26/2877.long Consensus recommendations for the diagnosis and clinical management of Rosai-Dorfman-Destombes disease] [https://www.ncbi.nlm.nih.gov/pubmed/29720485 PubMed] | ||
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+ | ==[https://www.nccn.org NCCN]== | ||
+ | *[https://www.nccn.org/professionals/physician_gls/pdf/histiocytic_neoplasms.pdf NCCN Guideliines - Histiocytic Neoplasms] | ||
=All lines of therapy= | =All lines of therapy= |
Revision as of 13:22, 9 March 2021
Section editor | |
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Gaurav Goyal, MD UAB Birmingham, AL ![]() |
1 regimens on this page
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Guidelines
Consensus guidelines
- 2018: Abla et al. Consensus recommendations for the diagnosis and clinical management of Rosai-Dorfman-Destombes disease PubMed
NCCN
All lines of therapy
Cobimetinib monotherapy
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Regimen
Study | Evidence |
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Diamond et al. 2019 (MSK 15-216) | Pilot, <20 pts in this arm |
Note: there were N=2 patients with this type of histiocytosis.
Targeted therapy
- Cobimetinib (Cotellic) 60 mg PO once per day on days 1 to 21
28-day cycles
References
- MSK 15-216: Diamond EL, Durham BH, Ulaner GA, Drill E, Buthorn J, Ki M, Bitner L, Cho H, Young RJ, Francis JH, Rampal R, Lacouture M, Brody LA, Ozkaya N, Dogan A, Rosen N, Iasonos A, Abdel-Wahab O, Hyman DM. Efficacy of MEK inhibition in patients with histiocytic neoplasms. Nature. 2019 Mar;567(7749):521-524. Epub 2019 Mar 13. link to original article contains verified protocol link to PMC article PubMed