Difference between revisions of "Carboplatin (Paraplatin)"

Revision as of 02:03, 25 February 2020

General information

Class/mechanism: Platinum analog, alkylating-like, producing predominantly interstrand DNA crosslinks that are cell-cycle nonspecific.^[1]^[2]

Route: IV
Extravasation: irritant

For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp,Medscape, UpToDate (courtesy of Lexicomp), or the prescribing information.^[1]

Dosing information

Carboplatin AUC calculator^[3]

Calvert formula

Calvert AH, Newell DR, Gumbrell LA, O'Reilly S, Burnell M, Boxall FE, Siddik ZH, Judson IR, Gore ME, Wiltshaw E. Carboplatin dosage: prospective evaluation of a simple formula based on renal function. J Clin Oncol. 1989 Nov;7(11):1748-56. link to original article contains verified formula PubMed

Diseases for which it is used

Patient drug information

History of changes in FDA indication

3/3/1989: Initial FDA approval

Also known as

Code name: JM8
Brand names:

Synonyms
Biocarb	Biocarbo	Bioplatinex	Biovinate	Blastocarb	Bonaplatin	Boplatex	Carbo
Carbokem	Carbomedac	Carbomerck	Carboplat	Carboplatine	Carboplatino	Carboplatinum	Carbosin
Carbotanil	Carbotec	Carbotinol	Careptin	Carplan	Carplanil	Carpsol	Crobextin
Cycloplatin	Cycloplatinum	Emorzim	Erbakar	Ercar	Fauldcarbo	Ifacap	Kemocarb
Megaplatin	Nealorin	Neocarb	Neocarbo	Oncocarb	Paraplatin	Paraplatine	Pharmaplatin
Platamine CS	Platinwas	Ribocarbo	Tecnocarb	Vancel	CBDCA

References

[insert-1] 1.0 ^1.1 Carboplatin (Paraplatin) package insert

[2] Carboplatin (Paraplatin) package insert (locally hosted backup)

[3] Carboplatin AUC calculator

[4] Carboplatin (Paraplatin) patient drug information (Chemocare)

[5] Carboplatin (Paraplatin) patient drug information (UpToDate)

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@@ Line 10: / Line 10: @@
 *[http://www.globalrph.com/carboplatin.htm Carboplatin AUC calculator]<ref>[http://www.globalrph.com/carboplatin.htm Carboplatin AUC calculator]</ref>
 ===Calvert formula===
-* Calvert AH, Newell DR, Gumbrell LA, O'Reilly S, Burnell M, Boxall FE, Siddik ZH, Judson IR, Gore ME, Wiltshaw E. Carboplatin dosage: prospective evaluation of a simple formula based on renal function. J Clin Oncol. 1989 Nov;7(11):1748-56. [http://jco.ascopubs.org/content/7/11/1748.long link to original article] '''contains verified formula''' [https://www.ncbi.nlm.nih.gov/pubmed/2681557 PubMed]
+* Calvert AH, Newell DR, Gumbrell LA, O'Reilly S, Burnell M, Boxall FE, Siddik ZH, Judson IR, Gore ME, Wiltshaw E. Carboplatin dosage: prospective evaluation of a simple formula based on renal function. J Clin Oncol. 1989 Nov;7(11):1748-56. [http://jco.ascopubs.org/content/7/11/1748.long link to original article] '''contains verified formula''' [https://pubmed.ncbi.nlm.nih.gov/2681557 PubMed]
 ==Diseases for which it is used==