Trastuzumab and hyaluronidase (Herceptin Hylecta)

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Mechanism of action

From the NCI Drug Dictionary: A ready-to-use combination of trastuzumab, a recombinant humanized monoclonal antibody directed against the human epidermal growth factor receptor 2 (HER2; receptor tyrosine-protein kinase erbB-2), and hyaluronidase-oysk, a recombinant human hyaluronidase PH20 (rHuPH20), that may be used for the treatment of HER2-overexpressing breast cancers. Upon subcutaneous administration, hyaluronidase-oysk temporarily breaks down the hyaluronan barrier, which decreases viscosity of, and allows trastuzumab to spread rapidly through the interstitial space. This improves access to lymphatic and capillary vessels and facilitates the absorption of trastuzumab into the bloodstream.

Diseases for which it is used

History of changes in FDA indication

Also known as

  • Generic name: trastuzumab-oysk and hyaluronidase
  • Brand name: Herceptin Hylecta