Tisagenlecleucel (Kymriah)

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Mechanism of action

  • From the NCI Drug Dictionary: Autologous T lymphocytes transduced with a modified lentiviral vector expressing a chimeric antigen receptor (CAR) consisting of an anti-CD19 scFv (single chain variable fragment) and the zeta chain of the TCR/CD3 complex (CD3-zeta), coupled to the signaling domain of 4-1BB (CD137), with potential immunomodulating and antineoplastic activities. Upon transfusion, tisagenlecleucel direct the T lymphocytes to CD19-expressing tumor cells, thereby inducing a selective toxicity in CD19-expressing tumor cells.

Diseases for which it is used

History of changes in FDA indication

Also known as

  • Code name: CTL019
  • Generic name: tisagenlecleucel-T
  • Brand name: Kymriah