Ribociclib (Kisqali)

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General information

Class/mechanism: Cyclin-dependent kinase (CDK) 4 and 6 inhibitor. Ribociclib inhibits DNA synthesis and cancer cell growth by blocking activity of the cyclin D-CDK4/6 complex which regulates cell cycle progression and cellular proliferation by phosphorylating the retinoblastoma protein (pRb). Inhibiting pRb phosphorylation has been observed to lead to cell cycle arrest in the G1 phase.[1][2][3]
Route: PO
Extravasation: n/a

Diseases for which it is used

Patient drug information

History of changes in FDA indication

Also known as

  • Code names: LEE011, LEE-011
  • Brand name: Kisqali

References