Plicamycin (Mithracin)

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General information

Class/mechanism: Antibiotic oncologic, intercalates DNA base pairs, and inhibits DNA and RNA synthesis. Has been used for hypercalcemia; lowers serum calcium levels independent of cytotoxic activity by blocking parathyroid hormone action on osteoclasts.[1][2]
Route: IV
Extravasation: irritant/vesicant

For conciseness and simplicity, currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]

Patient drug information

Diseases for which it was used

History of changes in FDA indication

  • 1970: Original approval for an unclear indication. (No supporting studies are cited)

Also known as

  • Generic name: mithramycin
  • Brand name: Mithracin