Cutaneous T-cell lymphoma - null regimens

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The purpose of this page is to provide references to "null therapy" such as placebo and observation. While not clinically relevant, these references provide further insight into the historical development of the treatment landscape. See the main CTCL page for current regimens.

Relapsed or refractory



Study Dates of enrollment Evidence Comparator Comparative Efficacy
Prince et al. 2010 (L4389-11) NR Phase 3 (C) Denileukin diftitox Inferior PFS


  1. L4389-11: Prince HM, Duvic M, Martin A, Sterry W, Assaf C, Sun Y, Straus D, Acosta M, Negro-Vilar A. Phase III placebo-controlled trial of denileukin diftitox for patients with cutaneous T-cell lymphoma. J Clin Oncol. 2010 Apr 10;28(11):1870-7. Epub 2010 Mar 8. link to original article contains dosing details in manuscript PubMed Clinical Trial Registry