Autoimmune cytopenias

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2 regimens on this page
2 variants on this page


This is an umbrella category that includes Felty's syndrome (autoimmune neutropenia), autoimmune thrombocytopenia (ITP), autoimmune hemolytic anemia (AIHA), and Evan's syndrome (AIHA & ITP). Please see the respective page(s) for disease-specific therapies. This page includes regimens that were used more broadly.

Guidelines

British Society for Haematology

Relapsed/refractory

Alemtuzumab (Campath)

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Regimen

Study Evidence
Willis et al. 2001 Phase II

To be completed

References

  1. Willis F, Marsh JC, Bevan DH, Killick SB, Lucas G, Griffiths R, Ouwehand W, Hale G, Waldmann H, Gordon-Smith EC. The effect of treatment with Campath-1H in patients with autoimmune cytopenias. Br J Haematol. 2001 Sep;114(4):891-8.link to original article PubMed

Sirolimus (Rapamune)

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Regimen

Study Evidence
Bride et al. 2015 Phase II

6-month course, extended for those with a favorable response

References

  1. Bride KL, Vincent T, Smith-Whitley K, Lambert MP, Bleesing JJ, Seif AE, Manno CS, Casper J, Grupp SA, Teachey DT. Sirolimus is effective in relapsed/refractory autoimmune cytopenias: results of a prospective multi-institutional trial. Blood. 2016 Jan 7;127(1):17-28. Epub 2015 Oct 26. link to original article contains protocol PubMed