Class/mechanism: Selective and reversible factor Xa inhibitor. By inhibiting free and clotbound factor Xa in the coagulation cascade, apixaban inhibits prothrombinase activity, the conversion of prothrombin to thrombin, and the subsequent conversion of fibrinogen to fibrin. It does not need antithrombin III to exert its antithrombotic activity.
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.
Diseases for which it is used
- Atrial fibrillation
- Venous thromboembolism (VTE)
Patient drug information
History of changes in FDA indication
- 12/28/2012: FDA approved "to reduce the risk of stroke and dangerous blood clots (systemic embolism) in patients with atrial fibrillation that is not caused by a heart valve problem."
- 3/13/2014: FDA approved "for the prophylaxis of deep vein thrombosis (DVT), which may lead to pulmonary embolism (PE), in patients who have undergone hip or knee replacement surgery."
- 8/21/2014: FDA approved "for the treatment of DVT and PE, and for the reduction in the risk of recurrent DVT and PE following initial therapy."
- Apixaban (Eliquis) package insert
- Apixaban (Eliquis) package insert (locally hosted backup)
- Eliquis manufacturer's website
- Apixaban (Eliquis) patient drug information (UpToDate)
- FDA approves Eliquis to reduce the risk of stroke, blood clots in patients with non-valvular atrial fibrillation (FDA.gov)