Apatinib (Aitan)

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Mechanism of action

From the NCI Drug Dictionary: An orally bioavailable, small-molecule receptor tyrosine kinase inhibitor with potential antiangiogenic and antineoplastic activities. Apatinib selectively binds to and inhibits vascular endothelial growth factor receptor 2, which may inhibit VEGF-stimulated endothelial cell migration and proliferation and decrease tumor microvessel density. In addition, this agent mildly inhibits c-Kit and c-SRC tyrosine kinases.

Diseases for which it is established (work in progress)

Diseases for which it is used

Also known as

  • Code name: YN-968D1
  • Generic name: rivoceranib
  • Brand name: Aitan