Antithymocyte globulin, horse ATG (Atgam)
Class/mechanism: Contains antibodies against T-cell markers including CD2, CD3, CD4, CD8, CD11a, CD18, CD25, CD44, CD45, Beta-2 microglobulin, HLA Class I heavy chains, and HLA-DR. Exact mechanism not understood, but may involve removing T-cells from circulation and modifying T-cell activation, migration, proliferation, and cytotoxic effects.
Extravasation: no information
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Diseases for which it is used
Patient drug information
Also known as
Note: different brands of horse ATG are likely to be from different host animals and will thus have different constituents; they should not be considered necessarily interchangeable.
- Brand names: Atgam, Lymphoglobuline, Thymogam