Class/mechanism from the NCI Drug Dictionary: A human bispecific antibody targeting both epidermal growth factor receptor EGFR and hepatocyte growth factor receptor (HGFR; cMet), with potential antineoplastic activity. Upon administration, amivantamab simultaneously targets and binds to wild-type or certain mutant forms of both EGFR and cMet expressed on cancer cells, thereby preventing receptor phosphorylation. This prevents the activation of both EGFR- and cMet-mediated signaling pathways. In addition, binding results in receptor degradation, which further inhibits EGFR- and cMet-mediated signaling. JNJ-61186372 also causes antibody-dependent cellular cytotoxicity (ADCC). Altogether, this results in the inhibition of tumor cell proliferation.
Extravasation: no information
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Diseases for which it is used
Patient drug information
To be completed
History of changes in FDA indication
- 2021-05-21: Granted accelerated approval for adult patients with locally advanced or metastatic non-small cell lung cancer (NSCLC) with epidermal growth factor receptor (EGFR) exon 20 insertion mutations, as detected by an FDA-approved test, whose disease has progressed on or after platinum-based chemotherapy. (Based on CHRYSALIS)
History of changes in EMA indication
- 2021-12-09: Initial conditional approval
History of changes in Health Canada indication
- 2022-03-30: Initial notice of compliance with conditions for the treatment of adult patients with locally advanced or metastatic non-small cell lung cancer (NSCLC) with activating epidermal-growth factor receptor (EGFR) Exon 20 insertion mutations whose disease has progressed on or after platinum-based chemotherapy.
Also known as
- Code name: JNJ-61186372
- Generic name: amivantamab-vmjw
- Brand name: Rybrevant