Fotemustine (Muphoran)

Mechanism of action

From the NCI Drug Dictionary: A chloroethylating nitrosourea with antineoplastic activity. Fotemustine alkylates guanine by forming chloroethyl adducts at the 6 position of guanine, resulting in N1-guanine and N3-cytosine cross linkages, inhibition of DNA synthesis, cell cycle arrest, and finally apoptosis. This agent is lipophilic and crosses the blood-brain barrier.

Diseases for which it is used

• Diffuse large B-cell lymphoma
• Classical Hodgkin lymphoma
• Melanoma
  • CNS melanoma
  • Uveal melanoma

Also known as

• Brand names: Muphoran, Mustophoran