Neuroblastoma - historical
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The purpose of this page is to provide references to regimens that are obsolete, outdated, or of historical interest only. As a general rule, this includes the inferior arm(s) of a randomized study, unless said regimens continue to be recommended by trustworthy sources such as the NCCN Guidelines. Is there a regimen missing from this list? See the main neuroblastoma page for current regimens.
2 regimens on this page
2 variants on this page
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High Risk
COG ANBL0532
Consolidation,
Chemotherapy,
Day 0 Corresponds to PBSC Infusion
- Melphalan (Alkeran) by the following criteria:
- Patients with GFR ≥ 100 mL/min and ≤ 12 kg: 2.3 mg/kg IV over 15 to 30 minutes once daily on days -7, -6, -5
- Patients with GFR ≥ 100 mL/min and > 12 kg: 70 mg/m2 IV over 15 to 30 minutes once daily on days -7, -6, -5
- Patients with GFR < 100 mL/min and ≥ 60 mL/min and are > 12 kg: 60 mg/m2 IV over 15 to 30 minutes once daily on days -7, -6, -5
- Patients with GFR < 100 mL/min and ≥ 60 mL/min and are ≤ 12 kg: 2 mg/kg IV over 15 to 30 minutes once daily on days -7, -6, -5
- Etoposide (Vepesid) by the following criteria:
- Patients with GFR ≥ 100 mL/min and ≤ 12 kg: 11.3 mg/kg IV over 24 hours once daily on days -7, -6, -5, -4
- Patients with GFR ≥ 100 mL/min and > 12 kg: 338 mg/m2 IV over 24 hours once daily on days -7, -6, -5, -4
- Patients with GFR < 100 mL/min and ≥ 60 mL/min and are > 12 kg: 200 mg/m2 IV over 24 hours once daily on days -7, -6, -5, -4
- Patients with GFR < 100 mL/min and ≥ 60 mL/min and are ≤ 12 kg: 6.7 mg/kg IV over 24 hours once daily on days -7, -6, -5, -4
- Carboplatin (Paraplatin) by the following criteria:
- Patients with GFR ≥ 100 mL/min and ≤ 12 kg: 14.2 mg/kg IV over 24 hours once daily on days -7, -6, -5, -4
- Patients with GFR ≥ 100 mL/min and > 12 kg: 425 mg/m2 IV over 24 hours once daily on days -7, -6, -5, -4
- Patients with GFR < 100 mL/min and ≥ 60 mL/min and are > 12 kg: AUC = 4.1 (Calvert Formula) (Max Daily Dose = 300 mg/m2) IV over 24 hours once daily on days -7, -6, -5, -4
- Patients with GFR < 100 mL/min and ≥ 60 mL/min and are ≤ 12 kg: AUC = 4.1 (Calvert Formula) (Max Daily Dose of 10 mg/kg) IV over 24 hours once daily on days -7, -6, -5, -4
36 Day Cycle
Supportive Therapy,
- Filgrastim (Neupogen) 5 μg/kg SubQ or IV once daily on day 0 and continuing until ANC > 2000 μL for 3 consecutive days
36 Day Cycle