Pancreatic cancer - historical

The purpose of this page is to provide references to regimens that are obsolete, outdated, or of historical interest only. As a general rule, this includes the inferior arm(s) of a randomized study, unless said regimens continue to be recommended by trustworthy sources such as the NCCN Guidelines. Is there a regimen missing from this list? See the main pancreatic cancer page for current regimens.

3 regimens on this page 3 variants on this page

Metastatic disease, all lines of therapy

SMF

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SMF: Streptozotocin, Mitomycin, 5-Fluorouracil

Regimen

Study	Years of enrollment	Evidence	Comparator	Comparative Efficacy
Kelsen et al. 1991	1987-1989	Phase III (C)	CAC	Superior OS

Chemotherapy

• Streptozocin (Zanosar)
• Mitomycin (Mutamycin)
• Fluorouracil (5-FU)

References

1. Kelsen D, Hudis C, Niedzwiecki D, Dougherty J, Casper E, Botet J, Vinciguerra V, Rosenbluth R. A phase III comparison trial of streptozotocin, mitomycin, and 5-fluorouracil with cisplatin, cytosine arabinoside, and caffeine in patients with advanced pancreatic carcinoma. Cancer. 1991 Sep 1;68(5):965-9. link to original article PubMed