Etoposide (Vepesid)

General information

Class/mechanism: Topoisomerase II inhibitor. Causes DNA strand breaks by interacting with DNA-topoisomerase II or by forming free radicals. Causes arrest at the G2 portion of the cell cycle, with dose dependent effects: at high concentrations, cells entering mitosis undergo lysis; at low concentrations, cells are inhibited from entering prophase.
Route: IV, PO
Extravasation: irritant

For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.

Diseases for which it is used

• Acute myeloid leukemia
• Acute promyelocytic leukemia
• Aggressive Non-Hodgkin lymphoma
• Bone cancer
• Cancer of Unknown Primary
• Central nervous system (CNS) cancer
• Esophageal cancer
• Follicular lymphoma
• Hepatobiliary cancer
• HIV-associated lymphoma
• Hodgkin lymphoma
• Hodgkin lymphoma, nodular lymphocyte-predominant
• Mantle cell lymphoma
• Multiple myeloma
• Neuroendocrine tumors
• Non-small cell lung cancer
• Ovarian cancer
• Sarcoma
• Small cell lung cancer
• T-cell lymphoma
• Testicular cancer
• Thymoma
• Transplant conditioning regimens

Patient drug information

• Etoposide (Vepesid) patient drug information (Chemocare)
• Etoposide (Vepesid) patient drug information (UpToDate)

Also known as

Abic Etoposide, Aside, Beposid, Bioposide, BO RUI, Bristol VP-16, Celltop, Citodox, Epocin, Eposid, Eposide, Eposido, Eposin, Epsidox, ETO, Etocris, Etomedac, Etonolver, Etopofos, Etopophos, Etopos, Etoposid, Etoposide Abic, Etoposid Ebewe, Etoposide Bigmar, Etoposide BVI, Etoposide Dakota, Etoposide DBL, Etoposide DUP, Etoposide Ebewe, Etoposide Eurocept, Etoposide Merck, Etoposide Pfizer, etoposide phosphate, Etoposide Teva, Etoposid Mayne, Etoposido, Etoposido Delta Farma, Etoposido Ferrer, Etoposido GI Kendr, Etoposido Servycal, Etoposido Varifarm, Etoposid Proreo, Etoposid Teva, Etopoxan, Etopul, Etosid, Etosin, Eunades CS, Euvaxon, Exitop, Fytop, Fytosid, HAI WEI LIN, Labimion, Lastet, Lastet S, Neoplaxol, Nexvep, Onkoposid, Optasid, P&U Etoposide, Percas, Posid, Posidon, Posyd, Riboposid, Sintopozid, Toposar, Toposide, Toposin, Topresid, Tosuben, Vepefos, Vepeside, Vepesid K, Vepesid S, Vepesid VP-16, Vepsid, Vepside, VP-16, VP-TEC, VP 16213