Carboplatin (Paraplatin)

General information

Class/mechanism: Platinum analog, alkylating-like, producing predominantly interstrand DNA crosslinks that are cell-cycle nonspecific.

• Carboplatin AUC calculator

Route: IV
Extravasation: irritant

For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp,Medscape, UpToDate (courtesy of Lexicomp), or the prescribing information.

Diseases for which it is used

• Adult T-cell leukemia-lymphoma
• Bladder cancer
• Breast cancer
• Central nervous system (CNS) cancer
• Cervical cancer
• Diffuse large B-cell lymphoma
• Esophageal cancer
• Ewing's sarcoma
• Extranodal NK/T-cell lymphoma, nasal type
• Glioblastoma
• Head and neck cancer
• Hodgkin lymphoma
• Melanoma
• Mesothelioma
• Non-small cell lung cancer
• Osteosarcoma
• Ovarian cancer
• Prostate cancer
• Small cell lung cancer
• Testicular cancer
• Thymoma
• Uterine cancer
• Unknown primary

Patient drug information

• Carboplatin (Paraplatin) patient drug information (Chemocare)
• Carboplatin (Paraplatin) patient drug information (UpToDate)

History of changes in FDA indication

• 3/3/1989: Initial FDA approval

Also known as

Synonyms
Abic Carboplatin	Biocarb	Biocarbo	Bioplatinex	Biovinate	Blastocarb	Blastocarb RU	BO BEI
Bonaplatin	Boplatex	Carbo	Carbo-Cell	Carbokem	Carbomedac	Carbomerck	Carbomerck Merk Hoei
Carboplat	Carboplatin-GRY	Carboplatin-Teva	Carboplatin Abic	Carboplatin D-W	Carboplatin DBL	Carboplatine	Carboplatine eurocept
Carboplatine Aguettant	Carboplatin Ebewe	Carboplatine Dakot	Carboplatine Dakota	Carboplatine Eurocept	Carboplatine G GAM	Carboplatine Mayne Pharma (BEN)	Carboplatine Merck
Carboplatine Teva	Carboplatin Hexal	Carboplatin Lens	Carboplatin Mayne	Carboplatino	Carboplatino Delta	Carboplatino Ferrer	Carboplatino Ferrer Farma
Carboplatino Filaxis	Carboplatino Martian	Carboplatino MAY	Carboplatino Microsules	Carboplatino Montedison	Carboplatino Pharmacia	Carboplatino PHU	Carboplatino Raffo
Carboplatino Rontag	Carboplatino Teva	Carboplatin Sanofi-Synthelabo	Carboplatinum	Carbosin	Carbotanil	Carbotec	Carbotinol
Careptin	Carplan	Carplanil	Carpsol	cis-Diammine(1	1-cyclobutanedicarboxylato)platinum(II)	Crobextin	Cycloplatin
Cycloplatinum	Emorzim	Erbakar	Ercar	Fauldcarbo	Ifacap	Kemocarb	Mega Carboplatin
Megaplatin	Nealorin	Neocarb	Neocarbo	Oncocarb	Oncocarbin AQ	P&U Carboplatin	Paraplatin AQ
Paraplatine	Paraplatin RTU	Pharmaplatin	Platamine CS	Platinwas	Ribocarbo	Ribocarbo-L	Tecnocarb
Trav Carboplatin	Vancel	CBDCA