Anal cancer

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Chemotherapy & radiation therapy

Fluorouracil (5-FU), Mitomycin (Mutamycin), radiation therapy

Regimen

• Fluorouracil (5-FU) 1000 mg/m2/day IV continuous infusion on days 1-4 and 29-32
• Mitomycin (Mutamycin) 10 mg/m2 (maximum of 20mg per dose) IV bolus on days 1 & 29
• Concurrent radiation therapy; at a minimum: 1.8 Gy per day, 5 days per week; 25 fractions given over 5 weeks total for a total of 45 Gy

References

1. Ajani JA, Winter KA, Gunderson LL, Pedersen J, Benson AB 3rd, Thomas CR Jr, Mayer RJ, Haddock MG, Rich TA, Willett C. Fluorouracil, mitomycin, and radiotherapy vs fluorouracil, cisplatin, and radiotherapy for carcinoma of the anal canal: a randomized controlled trial. JAMA. 2008 Apr 23;299(16):1914-21. link to original article contains protocol PubMed

Chemotherapy

Fluorouracil (5-FU), Cisplatin (Platinol)

Regimen

• Fluorouracil (5-FU) 1000 mg/m2/day IV continuous infusion on days 1-5
• Cisplatin (Platinol) 100 mg/m2 IV on day 2

28-day cycles

References

1. Faivre C, Rougier P, Ducreux M, Mitry E, Lusinchi A, Lasser P, Elias D, Eschwege F. [5-fluorouracile and cisplatinum combination chemotherapy for metastatic squamous-cell anal cancer]. [Article in French] Bull Cancer. 1999 Oct;86(10):861-5. link to original article & English summary contains protocol PubMed