Prostate cancer

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Metastatic castrate-resistant disease

Cabazitaxel (Jevtana)

Regimen

• Cabazitaxel (Jevtana) 25 mg/m2 IV over 1 hour on day 1
• Prednisone (Sterapred) 10 mg PO on days 1-21

21-day cycles x up to 10 cycles

Supportive medications:

• "Antihistamine, corticosteroid (dexamethasone 8 mg or equivalent), and histamine H2-antagonist (except cimetidine)" given at least 30 minutes before cabazitaxel

References

1. de Bono JS, Oudard S, Ozguroglu M, Hansen S, Machiels JP, Kocak I, Gravis G, Bodrogi I, Mackenzie MJ, Shen L, Roessner M, Gupta S, Sartor AO; TROPIC Investigators. Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial. Lancet. 2010 Oct 2;376(9747):1147-54. link to original article contains protocol PubMed

Mitoxantrone (Novantrone)

Regimen

• Mitoxantrone (Novantrone) 12 mg/m2 IV over 15-30 minutes on day 1
• Prednisone (Sterapred) 10 mg PO on days 1-21

21-day cycles x up to 10 cycles

References

1. de Bono JS, Oudard S, Ozguroglu M, Hansen S, Machiels JP, Kocak I, Gravis G, Bodrogi I, Mackenzie MJ, Shen L, Roessner M, Gupta S, Sartor AO; TROPIC Investigators. Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial. Lancet. 2010 Oct 2;376(9747):1147-54. link to original article contains protocol PubMed

Links

Partin tables to predict pathologic stage based on clinical TNM stage, PSA, and Gleason score