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Carboplatin & RT
Carboplatin & RT: Carboplatin & Radiation Therapy
Regimen variant #1, weekly carboplatin
Study | Dates of enrollment | Evidence | Comparator | Comparative Efficacy |
---|---|---|---|---|
Monk et al. 2023 (CALLA) | 2019-02-15 to 2020-12-10 | Phase 3 (C) | Carboplatin, UFT, RT | Did not meet primary endpoint of PFS |
Chemotherapy
- Carboplatin (Paraplatin) AUC 2 IV once per day on days 1, 8, 15, 22, 29
Radiotherapy
- Concurrent radiation therapy, 1.8 Gy per fraction on days 1 to 5, 8 to 12, 15 to 19, 22 to 26, 29 to 33 (45 Gy total in 25 fractions)
5-week course
Subsequent treatment
- Brachytherapy