Neuroblastoma - historical

Section editor transclusions

The purpose of this page is to provide references to regimens that are obsolete, outdated, or of historical interest only. As a general rule, this includes the inferior arm(s) of a randomized study, unless said regimens continue to be recommended by trustworthy sources such as the NCCN Guidelines. Is there a regimen missing from this list? See the main neuroblastoma page for current regimens.

2 regimens on this page 2 variants on this page

High Risk

COG ANBL0532

Consolidation,

Chemotherapy,

Day 0 Corresponds to PBSC Infusion

• Melphalan (Alkeran) by the following criteria:
  • Patients with GFR ≥ 100 mL/min and ≤ 12 kg: 2.3 mg/kg IV over 15 to 30 minutes once daily on days -7, -6, -5
  • Patients with GFR ≥ 100 mL/min and > 12 kg: 70 mg/m² IV over 15 to 30 minutes once daily on days -7, -6, -5
  • Patients with GFR < 100 mL/min and ≥ 60 mL/min and are > 12 kg: 60 mg/m² IV over 15 to 30 minutes once daily on days -7, -6, -5
  • Patients with GFR < 100 mL/min and ≥ 60 mL/min and are ≤ 12 kg: 2 mg/kg IV over 15 to 30 minutes once daily on days -7, -6, -5

• Etoposide (Vepesid) by the following criteria:
  • Patients with GFR ≥ 100 mL/min and ≤ 12 kg: 11.3 mg/kg IV over 24 hours once daily on days -7, -6, -5, -4
  • Patients with GFR ≥ 100 mL/min and > 12 kg: 338 mg/m² IV over 24 hours once daily on days -7, -6, -5, -4
  • Patients with GFR < 100 mL/min and ≥ 60 mL/min and are > 12 kg: 200 mg/m² IV over 24 hours once daily on days -7, -6, -5, -4
  • Patients with GFR < 100 mL/min and ≥ 60 mL/min and are ≤ 12 kg: 6.7 mg/kg IV over 24 hours once daily on days -7, -6, -5, -4

• Carboplatin (Paraplatin) by the following criteria:
  • Patients with GFR ≥ 100 mL/min and ≤ 12 kg: 14.2 mg/kg IV over 24 hours once daily on days -7, -6, -5, -4
  • Patients with GFR ≥ 100 mL/min and > 12 kg: 425 mg/m² IV over 24 hours once daily on days -7, -6, -5, -4
  • Patients with GFR < 100 mL/min and ≥ 60 mL/min and are > 12 kg: AUC = 4.1 (Calvert Formula) (Max Daily Dose = 300 mg/m²) IV over 24 hours once daily on days -7, -6, -5, -4
  • Patients with GFR < 100 mL/min and ≥ 60 mL/min and are ≤ 12 kg: AUC = 4.1 (Calvert Formula) (Max Daily Dose of 10 mg/kg) IV over 24 hours once daily on days -7, -6, -5, -4

36 Day Cycle

Supportive Therapy,

• Filgrastim (Neupogen) 5 μg/kg SubQ or IV once daily on day 0 and continuing until ANC > 2000 μL for 3 consecutive days

36 Day Cycle