Ifosfamide (Ifex)

General information

Class/mechanism: Nitrogen mustard, alkylator. Metabolites of ifosfamide interact with DNA to produce phosphotriesters and formation of DNA cross-links. Ifosfamide requires metabolic activation by microsomal liver enzymes to form its active metabolites.^[1]^[2]
Route: IV
Extravasation: irritant or neutral, depending on reference

A protective agent such as Mesna (Mesnex) should be used concurrently with ifosfamide to help prevent hemorrhagic cystitis.

For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.^[1]

Diseases for which it is used

Diseases for which it was used

Non-small cell lung cancer

Patient drug information

History of changes in FDA indication

12/30/1988: Initial approval in combination with certain other approved antineoplastic agents for third-line chemotherapy of germ cell testicular cancer. It should ordinarily be used in combination with a prophylactic agent for hemorrhagic cystitis, such as mesna

Also known as

Brand names:

Synonyms
Alquimid	Duvaxan	Fentul	Fosfidex	Haloxan
Holoxan	Holoxane	Ifex	IFO Cell	Ifocris
Ifolem	Ifomida	Ifomide	Ifos	Ifosfamida
Ifoxan	IFX	Ipamide	Isophosphamide	Isoxan
Macdafen	Mitoxana	Tronoxal

References

[insert-1] 1.0 ^1.1 ^1.2 Ifosfamide (Ifex) package insert

[2] Ifosfamide (Ifex) package insert (locally hosted backup)

[3] Ifosfamide (Ifex) patient drug information (Chemocare)

[4] Ifosfamide (Ifex) patient drug information (UpToDate)

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