Ifosfamide (Ifex)

General information

Class/mechanism: Nitrogen mustard, alkylator. Metabolites of ifosfamide interact with DNA to produce phosphotriesters and formation of DNA cross-links. Ifosfamide requires metabolic activation by microsomal liver enzymes to form its active metabolites.
Route: IV
Extravasation: irritant or neutral, depending on reference

• A protective agent such as Mesna (Mesnex) should be used concurrently with ifosfamide to help prevent hemorrhagic cystitis.

For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.

Diseases for which it is used

• Burkitt lymphoma
• CNS lymphoma
• Cervical cancer
• Diffuse large B-cell lymphoma
• Ewing sarcoma
• Extranodal NK- and T-cell lymphoma, nasal type
• HIV-associated lymphoma
• Hodgkin lymphoma
• Mantle cell lymphoma
• NK/T-cell lymphoma
• Osteosarcoma
• Penile cancer
• Rhabdomyosarcoma
• Soft tissue sarcoma
• Small cell lung cancer
• Testicular cancer
• Thymoma
• Endometrial cancer

Diseases for which it was used

• Non-small cell lung cancer

Patient drug information

• Ifosfamide (Ifex) patient drug information (Chemocare)
• Ifosfamide (Ifex) patient drug information (UpToDate)

History of changes in FDA indication

• 12/30/1988: Initial FDA approval

Also known as

• Brand names:

Synonyms
Alquimid	Duvaxan	Fentul	Fosfidex	Haloxan
Holoxan	Holoxane	Ifex	IFO Cell	Ifocris
Ifolem	Ifomida	Ifomide	Ifos	Ifosfamida
Ifoxan	IFX	Ipamide	Isophosphamide	Isoxan
Macdafen	Mitoxana	Tronoxal