Section editor
	Wayne H. Liang, MD, MS Birmingham, AL LinkedIn Twitter: WayneLiangMD

3 regimens on this page 3 variants on this page

All lines of therapy

Dactinomycin monotherapy

back to top

Study	Evidence	Comparator	Efficacy
Wolff et al. 1968	Randomized (E)	Single course of dactinomycin	Seems to have superior RFS

6-week cycle for 3 cycles, then 3-month cycle for 4 cycles

Wolff JA, Newton WA Jr, Krivit W, D'Angio GJ. Single versus multiple dose dactinomycin therapy of Wilms's tumor: a controlled co-operative study conducted by the Children's Cancer Study Group A (formerly Acute Leukemia Co-operative Chemotherapy Group A). N Engl J Med. 1968 Aug 8;279(6):290-4. link to original article PubMed
1. Update: Wolff JA, D'Angio G, Hartmann J, Krivit W, Newton WA Jr. Long-term evaluation of single versus multiple courses of actinomycin D therapy of Wilms's tumor. N Engl J Med. 1974 Jan 10;290(2):84-6. link to original article contains verified protocol PubMed

back to top

Study	Evidence	Comparator	Efficacy
de Kraker et al. 2004 (SIOP 93-01)	Phase III (E)	Prolonged chemotherapy	Equivalent EFS

SIOP 93-01: de Kraker J, Graf N, van Tinteren H, Pein F, Sandstedt B, Godzinski J, Tournade MF; SIOP. Reduction of postoperative chemotherapy in children with stage I intermediate-risk and anaplastic Wilms' tumour (SIOP 93-01 trial): a randomised controlled trial. Lancet. 2004 Oct 2-8;364(9441):1229-35. link to SD article PubMed