Difference between revisions of "Melphalan (Alkeran)"
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*[[Acute myeloid leukemia]] | *[[Acute myeloid leukemia]] | ||
*[[Acute promyelocytic leukemia]] | *[[Acute promyelocytic leukemia]] | ||
| − | |||
| − | |||
*[[Ewing sarcoma]] | *[[Ewing sarcoma]] | ||
| − | |||
| − | |||
*[[Hodgkin lymphoma]] | *[[Hodgkin lymphoma]] | ||
| − | |||
| − | |||
| − | |||
*[[Neuroblastoma]] | *[[Neuroblastoma]] | ||
| − | *[[Plasma cell leukemia]] | + | *Non-Hodgkin lymphoma |
| + | **[[CNS lymphoma]] | ||
| + | **[[Diffuse large B-cell lymphoma]] | ||
| + | **[[Follicular lymphoma]] | ||
| + | **[[HIV-associated lymphoma]] | ||
| + | **[[Mantle cell lymphoma]] | ||
| + | **[[Peripheral T-cell lymphoma]] | ||
| + | *Plasma cell dyscrasia | ||
| + | **[[Light-chain (AL) amyloidosis]] | ||
| + | **[[Multiple myeloma]] | ||
| + | **[[Plasma cell leukemia]] | ||
==Diseases for which it was used== | ==Diseases for which it was used== | ||
| Line 62: | Line 65: | ||
[[Category:Multiple myeloma medications]] | [[Category:Multiple myeloma medications]] | ||
[[Category:Neuroblastoma medications]] | [[Category:Neuroblastoma medications]] | ||
| + | [[Category:Peripheral T-cell lymphoma medications]] | ||
[[Category:Plasma cell leukemia medications]] | [[Category:Plasma cell leukemia medications]] | ||
Revision as of 01:39, 16 May 2022
General information
Class/mechanism: Nitrogen mustard, alkylator. Melphalan is a bischloroethylamine alkylating agent that crosslinks DNA by binding at the N7 position of guanine, with activity against resting and proliferating cells.[1][2]
Route: IV, PO
Extravasation: irritant or neutral, depending on reference
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]
Diseases for which it is used
- Acute myeloid leukemia
- Acute promyelocytic leukemia
- Ewing sarcoma
- Hodgkin lymphoma
- Neuroblastoma
- Non-Hodgkin lymphoma
- Plasma cell dyscrasia
Diseases for which it was used
Patient drug information
- Melphalan (Alkeran) patient drug information (Chemocare)[3]
- Melphalan (Alkeran) patient drug information (UpToDate)[4]
History of changes in FDA indication
- 1/17/1964: Initial FDA approval[5]
- Indicated for the palliative treatment of multiple myeloma and for the palliation of non-resectable epithelial carcinoma of the ovary.
Also known as
- Generic names: L-PAM, L-Sacrolysin, L-Sarcolysin, MPL, phenylalanine mustard
- Brand names: Alkeran, Alkerana, Evomela, Levofolan, Melfalan
References
- Drugs
- Intravenous medications
- Oral medications
- Irritant
- Neutral
- Alkylating agents
- Nitrogen mustards
- Acute myeloid leukemia medications
- Acute promyelocytic leukemia medications
- CNS lymphoma medications
- Diffuse large B-cell lymphoma medications
- Ewing sarcoma medications
- Follicular lymphoma medications
- HIV-associated lymphoma medications
- Hodgkin lymphoma medications
- Light-chain (AL) amyloidosis medications
- Mantle cell lymphoma medications
- Multiple myeloma medications
- Neuroblastoma medications
- Peripheral T-cell lymphoma medications
- Plasma cell leukemia medications
- Breast cancer medications (historic)
- Ovarian cancer medications (historic)
- FDA approved in 1964
- WHO Essential Cancer Medicine