Difference between revisions of "Isotretinoin (Accutane)"
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==Diseases for which it is used== | ==Diseases for which it is used== | ||
| + | *[[Cutaneous squamous cell carcinoma]] | ||
*[[Neuroblastoma]] | *[[Neuroblastoma]] | ||
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| + | ==Diseases for which it was used== | ||
| + | *[[Renal cell carcinoma - historical|Renal cell carcinoma]] | ||
== Patient Drug Information== | == Patient Drug Information== | ||
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[[Category:Neuroblastoma medications]] | [[Category:Neuroblastoma medications]] | ||
[[Category:Cutaneous squamous cell carcinoma medications]] | [[Category:Cutaneous squamous cell carcinoma medications]] | ||
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| + | [[Category:Renal cell carcinoma medications (historic)]] | ||
[[Category:FDA approved in 1982]] | [[Category:FDA approved in 1982]] | ||
Revision as of 02:12, 28 April 2022
Mechanism of action
From the NCI Drug Dictionary: A naturally-occurring retinoic acid with potential antineoplastic activity. Isotretinoin binds to and activates nuclear retinoic acid receptors (RARs); activated RARs serve as transcription factors that promote cell differentiation and apoptosis. This agent also exhibits immunomodulatory and anti-inflammatory responses and inhibits ornithine decarboxylase, thereby decreasing polyamine synthesis and keratinization.
Diseases for which it is used
Diseases for which it was used
Patient Drug Information
Also known as
- Code name: Ro 4-3780
- Generic names: 13-cis-retinoic acid, 13-cis-vitamin A acid, 13-CRA, cis-retinoic acid, isotretinoinum, neovitamin A
- Brand names: Absorica, Accure, Accutane, Amnesteem, Cistane, Claravis, Isotrex, Isotrexin, Myorisan, Oratane, Roaccutan, Roaccutane, Roacutan, Sotret, Zenatane