Difference between revisions of "Ifosfamide (Ifex)"
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==Diseases for which it is used== | ==Diseases for which it is used== | ||
| + | *[[B-cell acute lymphoblastic leukemia, Ph-positive, pediatric]] | ||
*[[Burkitt lymphoma]] | *[[Burkitt lymphoma]] | ||
*[[CNS lymphoma]] | *[[CNS lymphoma]] | ||
*[[Cervical cancer]] | *[[Cervical cancer]] | ||
*[[Diffuse large B-cell lymphoma]] | *[[Diffuse large B-cell lymphoma]] | ||
| + | *[[Endometrial cancer]] | ||
*[[Ewing sarcoma]] | *[[Ewing sarcoma]] | ||
*[[Extranodal NK- and T-cell lymphoma, nasal type]] | *[[Extranodal NK- and T-cell lymphoma, nasal type]] | ||
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*[[Testicular cancer]] | *[[Testicular cancer]] | ||
*[[Thymoma]] | *[[Thymoma]] | ||
| − | *[[ | + | *[[T-cell acute lymphoblastic leukemia, pediatric]] |
==Diseases for which it was used== | ==Diseases for which it was used== | ||
*[[Non-small cell lung cancer_-_historical|Non-small cell lung cancer]] | *[[Non-small cell lung cancer_-_historical|Non-small cell lung cancer]] | ||
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[[Category:Burkitt lymphoma medications]] | [[Category:Burkitt lymphoma medications]] | ||
| + | [[Category:B-cell acute lymphoblastic leukemia medications]] | ||
[[Category:CNS lymphoma medications]] | [[Category:CNS lymphoma medications]] | ||
[[Category:Cervical cancer medications]] | [[Category:Cervical cancer medications]] | ||
[[Category:Diffuse large B-cell lymphoma medications]] | [[Category:Diffuse large B-cell lymphoma medications]] | ||
| + | [[Category:Endometrial cancer medications]] | ||
[[Category:Ewing sarcoma medications]] | [[Category:Ewing sarcoma medications]] | ||
[[Category:Extranodal NK- and T-cell lymphoma, nasal type medications]] | [[Category:Extranodal NK- and T-cell lymphoma, nasal type medications]] | ||
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[[Category:Testicular cancer medications]] | [[Category:Testicular cancer medications]] | ||
[[Category:Thymoma medications]] | [[Category:Thymoma medications]] | ||
| − | [[Category: | + | [[Category:T-cell acute lymphoblastic leukemia medications]] |
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| + | [[Category:Non-small cell lung cancer medications (historic)]] | ||
[[Category:FDA approved in 1988]] | [[Category:FDA approved in 1988]] | ||
[[Category:WHO Essential Cancer Medicine]] | [[Category:WHO Essential Cancer Medicine]] | ||
Revision as of 21:18, 25 April 2022
General information
Class/mechanism: Nitrogen mustard, alkylator. Metabolites of ifosfamide interact with DNA to produce phosphotriesters and formation of DNA cross-links. Ifosfamide requires metabolic activation by microsomal liver enzymes to form its active metabolites.[1][2]
Route: IV
Extravasation: irritant or neutral, depending on reference
- A protective agent such as Mesna (Mesnex) should be used concurrently with ifosfamide to help prevent hemorrhagic cystitis.
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]
Diseases for which it is used
- B-cell acute lymphoblastic leukemia, Ph-positive, pediatric
- Burkitt lymphoma
- CNS lymphoma
- Cervical cancer
- Diffuse large B-cell lymphoma
- Endometrial cancer
- Ewing sarcoma
- Extranodal NK- and T-cell lymphoma, nasal type
- HIV-associated lymphoma
- Hodgkin lymphoma
- Mantle cell lymphoma
- NK- and T-cell lymphoma
- Osteosarcoma
- Penile cancer
- Rhabdomyosarcoma
- Soft tissue sarcoma
- Small cell lung cancer
- Testicular cancer
- Thymoma
- T-cell acute lymphoblastic leukemia, pediatric
Diseases for which it was used
Patient drug information
- Ifosfamide (Ifex) package insert[1]
- Ifosfamide (Ifex) patient drug information (Chemocare)[3]
- Ifosfamide (Ifex) patient drug information (UpToDate)[4]
History of changes in FDA indication
- 12/30/1988: Initial approval in combination with certain other approved antineoplastic agents for third-line chemotherapy of germ cell testicular cancer. It should ordinarily be used in combination with a prophylactic agent for hemorrhagic cystitis, such as mesna
Also known as
- Brand names:
| Synonyms | ||||
|---|---|---|---|---|
| Alquimid | Duvaxan | Fentul | Fosfidex | Haloxan |
| Holoxan | Holoxane | Ifex | IFO Cell | Ifocris |
| Ifolem | Ifomida | Ifomide | Ifos | Ifosfamida |
| Ifoxan | IFX | Ipamide | Isophosphamide | Isoxan |
| Macdafen | Mitoxana | Tronoxal | ||
References
Categories:
- Drugs
- Intravenous medications
- Irritant
- Neutral
- Nitrogen mustards
- Burkitt lymphoma medications
- B-cell acute lymphoblastic leukemia medications
- CNS lymphoma medications
- Cervical cancer medications
- Diffuse large B-cell lymphoma medications
- Endometrial cancer medications
- Ewing sarcoma medications
- Extranodal NK- and T-cell lymphoma, nasal type medications
- HIV-associated lymphoma medications
- Hodgkin lymphoma medications
- Mantle cell lymphoma medications
- NK- and T-cell lymphoma medications
- Osteosarcoma medications
- Penile cancer medications
- Rhabdomyosarcoma medications
- Soft tissue sarcoma medications
- Small cell lung cancer medications
- Testicular cancer medications
- Thymoma medications
- T-cell acute lymphoblastic leukemia medications
- Non-small cell lung cancer medications (historic)
- FDA approved in 1988
- WHO Essential Cancer Medicine