Difference between revisions of "Abemaciclib (Verzenio)"
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==Diseases for which it is used== | ==Diseases for which it is used== | ||
| − | *[[Breast cancer]] | + | *[[Breast cancer, ER-positive]] |
==History of changes in FDA indication== | ==History of changes in FDA indication== | ||
Revision as of 20:58, 4 June 2021
Mechanism of action
From NCI Drug Dictionary: An orally available cyclin-dependent kinase (CDK) inhibitor that targets the CDK4 (cyclin D1) and CDK6 (cyclin D3) cell cycle pathway, with potential antineoplastic activity. Abemaciclib specifically inhibits CDK4 and 6, thereby inhibiting retinoblastoma (Rb) protein phosphorylation in early G1.
Diseases for which it is used
History of changes in FDA indication
- 9/28/2017: FDA approved in combination with fulvestrant for women with HR-positive, HER2-negative advanced or metastatic breast cancer with disease progression following endocrine therapy. (Based on MONARCH 2)
- 9/28/2017: FDA approved as monotherapy for women and men with HR-positive, HER2-negative advanced or metastatic breast cancer with disease progression following endocrine therapy and prior chemotherapy in the metastatic setting. (Based on MONARCH 1)
- 2/26/2018: FDA approved in combination with an aromatase inhibitor as initial endocrine-based therapy for postmenopausal women with hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative advanced or metastatic breast cancer. (Based on MONARCH 3)
Manufacturer Package Insert
Also known as
- Code name: LY2835219
- Brand names: Verzenio, Verzenios