Difference between revisions of "Ifosfamide (Ifex)"
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==General information== | ==General information== | ||
| − | Class/mechanism: Nitrogen mustard, alkylator. Metabolites of ifosfamide interact with DNA to produce phosphotriesters and formation of DNA cross-links. Ifosfamide requires metabolic activation by microsomal liver enzymes to form its active metabolites.<ref name="insert">[https://www.accessdata.fda.gov/drugsatfda_docs/label/ | + | Class/mechanism: Nitrogen mustard, alkylator. Metabolites of ifosfamide interact with DNA to produce phosphotriesters and formation of DNA cross-links. Ifosfamide requires metabolic activation by microsomal liver enzymes to form its active metabolites.<ref name="insert">[https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/019763s017lbl.pdf Ifosfamide (Ifex) package insert]</ref><ref>[[Media:ifosfamide.pdf | Ifosfamide (Ifex) package insert (locally hosted backup)]]</ref> |
<br>Route: IV | <br>Route: IV | ||
<br>Extravasation: [[irritant]] or [[neutral]], depending on reference | <br>Extravasation: [[irritant]] or [[neutral]], depending on reference | ||
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==Patient drug information== | ==Patient drug information== | ||
| + | *[https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/019763s017lbl.pdf Ifosfamide (Ifex) package insert]<ref name="insert"></ref> | ||
*[http://chemocare.com/bio/ifosfamide.asp Ifosfamide (Ifex) patient drug information (Chemocare)]<ref>[http://chemocare.com/bio/ifosfamide.asp Ifosfamide (Ifex) patient drug information (Chemocare)]</ref> | *[http://chemocare.com/bio/ifosfamide.asp Ifosfamide (Ifex) patient drug information (Chemocare)]<ref>[http://chemocare.com/bio/ifosfamide.asp Ifosfamide (Ifex) patient drug information (Chemocare)]</ref> | ||
*[http://www.uptodate.com/contents/ifosfamide-patient-drug-information Ifosfamide (Ifex) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/ifosfamide-patient-drug-information Ifosfamide (Ifex) patient drug information (UpToDate)]</ref> | *[http://www.uptodate.com/contents/ifosfamide-patient-drug-information Ifosfamide (Ifex) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/ifosfamide-patient-drug-information Ifosfamide (Ifex) patient drug information (UpToDate)]</ref> | ||
Revision as of 11:18, 4 April 2021
General information
Class/mechanism: Nitrogen mustard, alkylator. Metabolites of ifosfamide interact with DNA to produce phosphotriesters and formation of DNA cross-links. Ifosfamide requires metabolic activation by microsomal liver enzymes to form its active metabolites.[1][2]
Route: IV
Extravasation: irritant or neutral, depending on reference
- A protective agent such as Mesna (Mesnex) should be used concurrently with ifosfamide to help prevent hemorrhagic cystitis.
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]
Diseases for which it is used
- Burkitt lymphoma
- CNS lymphoma
- Cervical cancer
- Diffuse large B-cell lymphoma
- Ewing sarcoma
- Extranodal NK- and T-cell lymphoma, nasal type
- HIV-associated lymphoma
- Hodgkin lymphoma
- Mantle cell lymphoma
- NK- and T-cell lymphoma
- Osteosarcoma
- Penile cancer
- Rhabdomyosarcoma
- Soft tissue sarcoma
- Small cell lung cancer
- Testicular cancer
- Thymoma
- Endometrial cancer
Diseases for which it was used
Patient drug information
- Ifosfamide (Ifex) package insert[1]
- Ifosfamide (Ifex) patient drug information (Chemocare)[3]
- Ifosfamide (Ifex) patient drug information (UpToDate)[4]
History of changes in FDA indication
- 12/30/1988: Initial approval in combination with certain other approved antineoplastic agents for third-line chemotherapy of germ cell testicular cancer. It should ordinarily be used in combination with a prophylactic agent for hemorrhagic cystitis, such as mesna
Also known as
- Brand names:
| Synonyms | ||||
|---|---|---|---|---|
| Alquimid | Duvaxan | Fentul | Fosfidex | Haloxan |
| Holoxan | Holoxane | Ifex | IFO Cell | Ifocris |
| Ifolem | Ifomida | Ifomide | Ifos | Ifosfamida |
| Ifoxan | IFX | Ipamide | Isophosphamide | Isoxan |
| Macdafen | Mitoxana | Tronoxal | ||
References
Categories:
- Drugs
- Intravenous medications
- Irritant
- Neutral
- Nitrogen mustards
- Burkitt lymphoma medications
- CNS lymphoma medications
- Cervical cancer medications
- Diffuse large B-cell lymphoma medications
- Ewing sarcoma medications
- Extranodal NK- and T-cell lymphoma, nasal type medications
- HIV-associated lymphoma medications
- Hodgkin lymphoma medications
- Mantle cell lymphoma medications
- NK- and T-cell lymphoma medications
- Osteosarcoma medications
- Penile cancer medications
- Rhabdomyosarcoma medications
- Soft tissue sarcoma medications
- Small cell lung cancer medications
- Testicular cancer medications
- Thymoma medications
- Endometrial cancer medications
- FDA approved in 1988
- WHO Essential Cancer Medicine