Difference between revisions of "Mitoxantrone (Novantrone)"
m |
|||
| Line 17: | Line 17: | ||
*[[Prostate cancer]] | *[[Prostate cancer]] | ||
| + | [[Category:Anthracyclines]] | ||
==Patient drug information== | ==Patient drug information== | ||
*[http://www.accessdata.fda.gov/drugsatfda_docs/label/2009/019297s030s031lbl.pdf#page=36 Mitoxantrone (Novantrone) package insert PDF page 36-41]<ref name="insert"></ref> | *[http://www.accessdata.fda.gov/drugsatfda_docs/label/2009/019297s030s031lbl.pdf#page=36 Mitoxantrone (Novantrone) package insert PDF page 36-41]<ref name="insert"></ref> | ||
Revision as of 17:50, 7 January 2014
General information
Class/mechanism: Synthetic antineoplastic anthracenedione, intercalates into DNA, causing crosslinking and strand breaks. Mitoxantrone inhibits topoisomerase II, which helps to uncoil and repair damaged DNA. It also has been observed to interfere with RNA and has activity against resting and proliferating cells. In vitro, it has been observed to interfere with antigen presentation; inhibit B-cell, T-cell, and macrophage proliferation; and decrease secretion of interferon gamma, tumor necrosis factor-alpha (TNF-α), and interleukin-2 (IL-2).[1][2]
Route: IV
Extravasation: irritant (usually), vesicant (rare)
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]
Diseases for which it is used
- Acute myeloid leukemia
- Acute promyelocytic leukemia
- Aggressive Non-Hodgkin lymphoma
- Chronic lymphocytic leukemia (CLL) and Small lymphocytic lymphoma (SLL)
- Follicular lymphoma
- Hodgkin lymphoma
- Mantle cell lymphoma
- Marginal zone lymphoma
- Prostate cancer
Patient drug information
- Mitoxantrone (Novantrone) package insert PDF page 36-41[1]
- Mitoxantrone (Novantrone) patient drug information (Chemocare)[3]
- Mitoxantrone (Novantrone) patient drug information (UpToDate)[4]