Difference between revisions of "Breast cancer, BRCA-mutated"
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− | *[[Breast cancer BRCA1 | + | *[[Breast cancer BRCA1 & BRCA2 genetic testing]] |
*[https://oncomx.org/searchview/?gene=BRCA1 OncoMX -- BRCA1] | *[https://oncomx.org/searchview/?gene=BRCA1 OncoMX -- BRCA1] | ||
*[https://oncomx.org/searchview/?gene=BRCA2 OncoMX -- BRCA2] | *[https://oncomx.org/searchview/?gene=BRCA2 OncoMX -- BRCA2] |
Revision as of 16:40, 23 November 2019
10 regimens on this page
13 variants on this page
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Note: this page has regimens which are specific to breast cancer that is BRCA-mutated. Please see the main breast cancer page for other chemotherapy regimens.
Guidelines
ESMO
Advanced or metastatic disease, all lines of therapy
Olaparib monotherapy
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Variant #1, 100 mg twice per day
Study | Evidence |
---|---|
Tutt et al. 2010 | Phase II |
Chemotherapy
- Olaparib (Lynparza) 100 mg PO twice per day
Continued indefinitely
Variant #2, 300 mg twice per day
Study | Evidence | Comparator | Comparative Efficacy |
---|---|---|---|
Robson et al. 2017 (OlympiAD) | Phase III (E) | 1. Capecitabine 2. Eribulin 3. Vinorelbine |
Superior PFS |
Patients had confirmed deleterious or suspected deleterious germline BRCA mutation. This is the FDA-approved dose.
Chemotherapy
- Olaparib (Lynparza) 300 mg PO twice per day
Continued indefinitely
Variant #3, 400 mg twice per day
Study | Evidence |
---|---|
Tutt et al. 2010 | Phase II |
Kaufman et al. 2014 (Study 42) | Phase II |
Patients in Study 42 had germline BRCA1/2 mutations and had progressed after at least three lines of treatment for metastatic disease.
Chemotherapy
- Olaparib (Lynparza) 400 mg PO twice per day
Continued indefinitely
References
- Tutt A, Robson M, Garber JE, Domchek SM, Audeh MW, Weitzel JN, Friedlander M, Arun B, Loman N, Schmutzler RK, Wardley A, Mitchell G, Earl H, Wickens M, Carmichael J. Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and advanced breast cancer: a proof-of-concept trial. Lancet. 2010 Jul 24;376(9737):235-44. Epub 2010 Jul 6. link to original article PubMed
- Study 42: Kaufman B, Shapira-Frommer R, Schmutzler RK, Audeh MW, Friedlander M, Balmaña J, Mitchell G, Fried G, Stemmer SM, Hubert A, Rosengarten O, Steiner M, Loman N, Bowen K, Fielding A, Domchek SM. Olaparib monotherapy in patients with advanced cancer and a germline BRCA1/2 mutation. J Clin Oncol. 2015 Jan 20;33(3):244-50. Epub 2014 Nov 3. link to original article contains verified protocol PubMed
- OlympiAD: Robson M, Im SA, Senkus E, Xu B, Domchek SM, Masuda N, Delaloge S, Li W, Tung N, Armstrong A, Wu W, Goessl C, Runswick S, Conte P. Olaparib for metastatic breast cancer in patients with a germline BRCA mutation. N Engl J Med. 2017 Aug 10;377(6):523-533. Epub 2017 Jun 4. link to original article contains verified protocol PubMed
- Update: Robson ME, Tung N, Conte P, Im SA, Senkus E, Xu B, Masuda N, Delaloge S, Li W, Armstrong A, Wu W, Goessl C, Runswick S, Domchek SM. OlympiAD final overall survival and tolerability results: Olaparib versus chemotherapy treatment of physician's choice in patients with a germline BRCA mutation and HER2-negative metastatic breast cancer. Ann Oncol. 2019 Apr 1;30(4):558-566. link to original article link to PMC article PubMed
Talazoparib monotherapy
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Regimen
FDA-recommended dose |
Study | Evidence | Comparator | Comparative Efficacy |
---|---|---|---|
Litton et al. 2018 (EMBRACA) | Phase III (E-RT) | Physician's choice of: 1. Capecitabine 2. Eribulin 3. Gemcitabine 4. Vinorelbine |
Superior PFS |
Chemotherapy
- Talazoparib (Talzenna) 1 mg PO once per day
Continued indefinitely
References
- EMBRACA: Litton JK, Rugo HS, Ettl J, Hurvitz SA, Gonçalves A, Lee KH, Fehrenbacher L, Yerushalmi R, Mina LA, Martin M, Roché H, Im YH, Quek RGW, Markova D, Tudor IC, Hannah AL, Eiermann W, Blum JL. Talazoparib in patients with advanced breast cancer and a germline BRCA mutation. N Engl J Med. 2018 Aug 23;379(8):753-763. Epub 2018 Aug 15. link to original article contains protocol PubMed
Additional resources
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