Revision as of 17:47, 25 August 2018

Section editor
	James L. Chen, MD, MS Columbus, OH LinkedIn

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Note: this page is for subtype-nonspecific bone sarcoma regimens, and some subtypes with very few subtype-specific regimens. Please see the category page for links to other sarcoma types or use one of these links:

Guidelines

ESMO

Bone sarcomas: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. PubMed

NCCN

NCCN Guidelines - Bone Cancer

Chondrosarcoma, all lines of therapy

No standard chemotherapy for grades 1 to 3 conventional chondrosarcoma
Mesenchymal chondrosarcoma has been treated with Ewing's sarcoma regimens
Dedifferentiated chondrosarcoma has been treated with osteosarcoma regimens

Giant-cell tumor of bone, all lines of therapy

Denosumab monotherapy

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Regimen

Study	Evidence
Thomas et. al 2010	Phase II

Primary therapy

Denosumab (Xgeva) as follows:
- Cycle 1: 120 mg SC once per day on days 1, 8, 15
- Cycle 2 onwards: 120 mg SC once on day 1

Supportive medications

Calcium 500 mg PO once per day
Vitamin D 400 IU PO once per day

28-day cycles, given until complete tumor resection, progression of disease, or patient choice

References

Thomas D, Henshaw R, Skubitz K, Chawla S, Staddon A, Blay JY, Roudier M, Smith J, Ye Z, Sohn W, Dansey R, Jun S. Denosumab in patients with giant-cell tumour of bone: an open-label, phase 2 study. Lancet Oncol. 2010 Mar;11(3):275-80. link to original article contains verified protocol PubMed

Malignant fibrous histiocytoma (MFH) of bone, all lines of therapy

Malignant fibrous histiocytoma (MFH) of bone has been treated with osteosarcoma regimens

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-Is there a regimen missing from this list?  Would you like to share a different dosage/schedule or an additional reference for a regimen?  Have you noticed an error?  Do you have an idea that will help the site grow to better meet your needs and the needs of many others?  You are [[How_to_contribute|invited to contribute to the site]].
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-<big>Note: this page is a gathering place for the 10+ subtypes of bone sarcoma. Subtypes with substantial numbers of regimens will be moved to their own pages, with links preserved here.</big>
+<big>Note: this page is for subtype-nonspecific bone sarcoma regimens, and some subtypes with very few subtype-specific regimens. Please see the [[:Category:Bone sarcomas|category page]] for links to other sarcoma types or use one of these links:
+*[[Ewing's sarcoma]]
+*[[Osteosarcoma]]
+</big>
 =Guidelines=
 ==[http://www.esmo.org/ ESMO]==
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 *Mesenchymal chondrosarcoma has been treated with [[Ewing's sarcoma|Ewing's sarcoma regimens]]
 *Dedifferentiated chondrosarcoma has been treated with [[Osteosarcoma|osteosarcoma regimens]]
-=Ewing's sarcoma, all lines of therapy=
-*Please see the [[Ewing's sarcoma|dedicated Ewing's sarcoma page]].
 =Giant-cell tumor of bone, all lines of therapy=
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 =Malignant fibrous histiocytoma (MFH) of bone, all lines of therapy=
 *Malignant fibrous histiocytoma (MFH) of bone has been treated with [[Osteosarcoma|osteosarcoma regimens]]
-=Osteosarcoma, all lines of therapy=
-*Please see the [[osteosarcoma|dedicated osteosarcoma page]].
 [[Category:Bone sarcoma regimens]]
 [[Category:Disease-specific pages]]
 [[Category:Soft tissue sarcomas]]

Difference between revisions of "Bone sarcoma"