Bone sarcoma

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Section editor
Elizabeth J. Davis, MD
Vanderbilt University
Nashville, TN

1 regimens on this page
1 variants on this page

Note: this page is for subtype-nonspecific bone sarcoma regimens, and some subtypes with very few subtype-specific regimens. Please see the category page for links to other sarcoma types or use one of these links:




Chondrosarcoma, all lines of therapy

Giant-cell tumor of bone, all lines of therapy

Denosumab monotherapy

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Study Evidence
Thomas et. al 2010 Phase II


  • Denosumab (Xgeva) as follows:
    • Cycle 1: 120 mg SC once per day on days 1, 8, 15
    • Cycle 2 onwards: 120 mg SC once on day 1

Supportive medications

  • Calcium 500 mg PO once per day
  • Vitamin D 400 IU PO once per day

28-day cycles


  1. Thomas D, Henshaw R, Skubitz K, Chawla S, Staddon A, Blay JY, Roudier M, Smith J, Ye Z, Sohn W, Dansey R, Jun S. Denosumab in patients with giant-cell tumour of bone: an open-label, phase 2 study. Lancet Oncol. 2010 Mar;11(3):275-80. link to original article contains verified protocol PubMed

Malignant fibrous histiocytoma (MFH) of bone, all lines of therapy