Carboplatin (Paraplatin)

General information

Class/mechanism: Platinum analog, alkylating-like, producing predominantly interstrand DNA crosslinks that are cell-cycle nonspecific.

• Carboplatin AUC calculator

Route: IV
Extravasation: irritant

For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp,Medscape, UpToDate (courtesy of Lexicomp), or the prescribing information.

Diseases for which it is used

• Bladder cancer
• Bone cancer
• Breast cancer
• Cervical cancer
• Esophageal cancer
• Hodgkin lymphoma
• Melanoma
• Mesothelioma
• Non-small cell lung cancer
• Ovarian cancer
• Small cell lung cancer
• Testicular cancer
• Thymoma
• Unknown primary
• Uterine cancer

Patient drug information

• Carboplatin (Paraplatin) patient drug information (Chemocare)
• Carboplatin (Paraplatin) patient drug information (UpToDate)

History of changes in FDA indication

• 3/3/1989: Initial FDA approval

Also known as

Abic Carboplatin, Biocarb, Biocarbo, Bioplatinex, Biovinate, Blastocarb, Blastocarb RU, BO BEI, Bonaplatin, Boplatex, Carbo, Carbo-Cell, Carbokem, Carbomedac, Carbomerck, Carbomerck Merk Hoei, Carboplat, Carboplatin, Carboplatin-GRY, Carboplatin-Teva, Carboplatin Abic, Carboplatin D-W, Carboplatin DBL, Carboplatine, Carboplatine eurocept, Carboplatine Aguettant, Carboplatin Ebewe, Carboplatine Dakot, Carboplatine Dakota, Carboplatine Eurocept, Carboplatine G GAM, Carboplatine Mayne Pharma (BEN), Carboplatine Merck, Carboplatine Teva, Carboplatin Hexal, Carboplatin Lens, Carboplatin Mayne, Carboplatino, Carboplatino Delta, Carboplatino Ferrer, Carboplatino Ferrer Farma, Carboplatino Filaxis, Carboplatino Martian, Carboplatino MAY, Carboplatino Microsules, Carboplatino Montedison, Carboplatino Pharmacia, Carboplatino PHU, Carboplatino Raffo, Carboplatino Rontag, Carboplatino Teva, Carboplatin Sanofi-Synthelabo, Carboplatinum, Carbosin, Carbotanil, Carbotec, Carbotinol, Careptin, Carplan, Carplanil, Carpsol, cis-Diammine(1,1-cyclobutanedicarboxylato)platinum(II), Crobextin, Cycloplatin, Cycloplatinum, Emorzim, Erbakar, Ercar, Fauldcarbo, Ifacap, Kemocarb, Mega Carboplatin, Megaplatin, Nealorin, Neocarb, Neocarbo, Oncocarb, Oncocarbin AQ, P&U Carboplatin, Paraplatin AQ, Paraplatine, Paraplatin RTU, Pharmaplatin, Platamine CS, Platinwas, Ribocarbo, Ribocarbo-L, Tecnocarb, Trav Carboplatin, Vancel.