Difference between revisions of "Ifosfamide (Ifex)"
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==Diseases for which it is used== | ==Diseases for which it is used== | ||
| − | |||
| − | |||
*[[Burkitt lymphoma]] | *[[Burkitt lymphoma]] | ||
*[[CNS lymphoma]] | *[[CNS lymphoma]] | ||
*[[Cervical cancer]] | *[[Cervical cancer]] | ||
*[[Diffuse large B-cell lymphoma]] | *[[Diffuse large B-cell lymphoma]] | ||
| + | *[[Ewing's sarcoma]] | ||
*[[Extranodal NK/T-cell lymphoma, nasal type]] | *[[Extranodal NK/T-cell lymphoma, nasal type]] | ||
*[[HIV-associated lymphoma]] | *[[HIV-associated lymphoma]] | ||
*[[Hodgkin lymphoma]] | *[[Hodgkin lymphoma]] | ||
| + | *[[Mantle cell lymphoma]] | ||
*[[NK/T-cell lymphoma]] | *[[NK/T-cell lymphoma]] | ||
| + | *[[Osteosarcoma]] | ||
*[[Penile cancer]] | *[[Penile cancer]] | ||
*[[Soft tissue sarcoma]] | *[[Soft tissue sarcoma]] | ||
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*[[Thymoma]] | *[[Thymoma]] | ||
*[[Uterine cancer]] | *[[Uterine cancer]] | ||
| + | ==Diseases for which it was used== | ||
| + | *[[Non-small cell lung cancer - obsolete|Non-small cell lung cancer]] | ||
==Patient drug information== | ==Patient drug information== | ||
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==Also known as== | ==Also known as== | ||
{| border="1" style="text-align:center;" | {| border="1" style="text-align:center;" | ||
| − | !colspan=" | + | !colspan="5" align="center" style="background-color:#0066FF"| '''Synonyms''' |
|- | |- | ||
|Alquimid | |Alquimid | ||
| Line 53: | Line 56: | ||
|Ifomide | |Ifomide | ||
|Ifos | |Ifos | ||
| − | |Ifosfamida | + | |Ifosfamida |
|- | |- | ||
| − | |||
| − | |||
| − | |||
|Ifoxan | |Ifoxan | ||
|IFX | |IFX | ||
| − | |||
|Ipamide | |Ipamide | ||
|Isophosphamide | |Isophosphamide | ||
|Isoxan | |Isoxan | ||
| + | |- | ||
|Macdafen | |Macdafen | ||
|Mitoxana | |Mitoxana | ||
| − | |||
| − | |||
| − | |||
| − | |||
|Tronoxal | |Tronoxal | ||
| − | |||
|- | |- | ||
|} | |} | ||
| Line 79: | Line 74: | ||
[[Category:Drug index]] | [[Category:Drug index]] | ||
| − | |||
[[Category:Intravenous medications]] | [[Category:Intravenous medications]] | ||
[[Category:Irritant chemotherapy]] | [[Category:Irritant chemotherapy]] | ||
| Line 86: | Line 80: | ||
[[Category:Nitrogen mustards]] | [[Category:Nitrogen mustards]] | ||
| − | |||
[[Category:Burkitt lymphoma medications]] | [[Category:Burkitt lymphoma medications]] | ||
[[Category:CNS lymphoma medications]] | [[Category:CNS lymphoma medications]] | ||
[[Category:Cervical cancer medications]] | [[Category:Cervical cancer medications]] | ||
[[Category:Diffuse large B-cell lymphoma medications]] | [[Category:Diffuse large B-cell lymphoma medications]] | ||
| + | [[Category:Ewing's sarcoma medications]] | ||
[[Category:Extranodal NK/T-cell lymphoma, nasal type medications]] | [[Category:Extranodal NK/T-cell lymphoma, nasal type medications]] | ||
[[Category:HIV-associated lymphoma medications]] | [[Category:HIV-associated lymphoma medications]] | ||
[[Category:Hodgkin lymphoma medications]] | [[Category:Hodgkin lymphoma medications]] | ||
| + | [[Category:Mantle cell lymphoma medications]] | ||
[[Category:NK/T-cell lymphoma medications]] | [[Category:NK/T-cell lymphoma medications]] | ||
| + | [[Category:Osteosarcoma medications]] | ||
[[Category:Penile cancer medications]] | [[Category:Penile cancer medications]] | ||
[[Category:Soft tissue sarcoma medications]] | [[Category:Soft tissue sarcoma medications]] | ||
Revision as of 01:37, 28 January 2018
General information
Class/mechanism: Nitrogen mustard, alkylator. Metabolites of ifosfamide interact with DNA to produce phosphotriesters and formation of DNA cross-links. Ifosfamide requires metabolic activation by microsomal liver enzymes to form its active metabolites.[1][2]
Route: IV
Extravasation: irritant or neutral, depending on reference
- A protective agent such as Mesna (Mesnex) should be used concurrently with ifosfamide to help prevent hemorrhagic cystitis.
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]
Diseases for which it is used
- Burkitt lymphoma
- CNS lymphoma
- Cervical cancer
- Diffuse large B-cell lymphoma
- Ewing's sarcoma
- Extranodal NK/T-cell lymphoma, nasal type
- HIV-associated lymphoma
- Hodgkin lymphoma
- Mantle cell lymphoma
- NK/T-cell lymphoma
- Osteosarcoma
- Penile cancer
- Soft tissue sarcoma
- Small cell lung cancer
- Testicular cancer
- Thymoma
- Uterine cancer
Diseases for which it was used
Patient drug information
- Ifosfamide (Ifex) patient drug information (Chemocare)[3]
- Ifosfamide (Ifex) patient drug information (UpToDate)[4]
History of changes in FDA indication
- 12/30/1988: Initial FDA approval
Also known as
| Synonyms | ||||
|---|---|---|---|---|
| Alquimid | Duvaxan | Fentul | Fosfidex | Haloxan |
| Holoxan | Holoxane | Ifex | IFO Cell | Ifocris |
| Ifolem | Ifomida | Ifomide | Ifos | Ifosfamida |
| Ifoxan | IFX | Ipamide | Isophosphamide | Isoxan |
| Macdafen | Mitoxana | Tronoxal | ||
References
Categories:
- Drug index
- Intravenous medications
- Irritant chemotherapy
- Neutral chemotherapy
- Nitrogen mustards
- Burkitt lymphoma medications
- CNS lymphoma medications
- Cervical cancer medications
- Diffuse large B-cell lymphoma medications
- Ewing's sarcoma medications
- Extranodal NK/T-cell lymphoma, nasal type medications
- HIV-associated lymphoma medications
- Hodgkin lymphoma medications
- Mantle cell lymphoma medications
- NK/T-cell lymphoma medications
- Osteosarcoma medications
- Penile cancer medications
- Soft tissue sarcoma medications
- Small cell lung cancer medications
- Testicular cancer medications
- Thymoma medications
- Uterine cancer medications
- Drugs FDA approved in 1988
- WHO Essential Cancer Medicine