Difference between revisions of "Anemia"
Jump to navigation
Jump to search
Warner-admin (talk | contribs) m (Text replacement - "Just 9 days left" to "Just 8 days left") |
m (Text replacement - "{|style="width: 100%; border-left:solid 20px #dc143c;border-right:solid 20px #dc143c;border-top:solid 20px #dc143c;border-bottom:solid 20px #dc143c;" align="center" | <span style="font-family:Arial; font-size:300%"> Just 8 days left to fill out a survey on how we can make HemOnc.org better and more useful.<br> '''Link:''' http://j.mp/2BlBaoQ </span> |}" to "{{:Editing test page 2}}") |
||
| Line 1: | Line 1: | ||
| − | { | + | {{:Editing test page 2}}<br>'''Use of this site is subject to you reading and agreeing with the terms set forth in the [[HemOnc.org_-_A_Hematology_Oncology_Wiki:General_disclaimer|disclaimer]]. If this is your first time visiting, we suggest you read the [[tutorial]].''' |
| − | |||
| − | |||
| − | |||
| − | |||
| − | |||
==Initial evaluation== | ==Initial evaluation== | ||
Revision as of 13:33, 25 January 2018
Carboplatin & Paclitaxel (CP)
CP: Carboplatin & Paclitaxel
Regimen
| Study | Dates of enrollment | Evidence | Comparator | Comparative Efficacy |
|---|---|---|---|---|
| Forde et al. 2022 (CheckMate 816) | 2017-2019 | Phase 3 (C) | 1a. CP & Nivolumab 1b. CVb & Nivolumab 1c. DC & Nivolumab |
Inferior EFS |
Note: there were additional comparator options depending on histology; see the respective histology-specific pages for more details. This study was conducted in the United States. The reason for the study was that an unanswered question at the time was whether adding an immune checkpoint inhibitor would improve outcomes.
Biomarker eligibility criteria
- CheckMate 816: No sensitizing EGFR or ALK mutations
Chemotherapy
- Carboplatin (Paraplatin) AUC 5 or 6 IV once on day 1
- Paclitaxel (Taxol) 175 or 200 mg/m2 IV once on day 1
21-day cycle for 3 cycles
Subsequent treatment
References
- CheckMate 816: Forde PM, Spicer J, Lu S, Provencio M, Mitsudomi T, Awad MM, Felip E, Broderick SR, Brahmer JR, Swanson SJ, Kerr K, Wang C, Ciuleanu TE, Saylors GB, Tanaka F, Ito H, Chen KN, Liberman M, Vokes EE, Taube JM, Dorange C, Cai J, Fiore J, Jarkowski A, Balli D, Sausen M, Pandya D, Calvet CY, Girard N; CheckMate 816 Investigators. Neoadjuvant Nivolumab plus Chemotherapy in Resectable Lung Cancer. N Engl J Med. 2022 May 26;386(21):1973-1985. Epub 2022 Apr 11. link to original article contains dosing details in manuscript PubMed NCT02998528
Start of hidden/commented information for virtual editor End of hidden/commented information for virtual editor
Start of comment inserted by visual editor(edited again by visual editor)
(edited again by visual editor end)End of comment inserted by visual editor
Use of this site is subject to you reading and agreeing with the terms set forth in the disclaimer. If this is your first time visiting, we suggest you read the tutorial.
Initial evaluation
May consist of:
- CBC with differential, MCV
- Basic metabolic panel (BMP)
- Liver function tests (LFTs)
- Reticulocyte count
- Iron, total iron binding capacity (TIBC), ferritin
- Vitamin B12 +/- methylmalonic acid & homocysteine
- Folic acid
- TSH
- Peripheral smear
- Clinical history, lifestyle factors (e.g. alcohol)
- Medications
GI bleeding?
- Stool occult blood
- EGD & colonoscopy
Hemolysis?
- LDH
- Haptoglobin
- Direct & indirect Coombs
- LFTs (direct, indirect, total bilirubin)
- Infectious: anaplasma, babesia, ehrlichia
Anemia of chronic disease/anemia chronic kidney disease
- Basic metabolic panel (BMP) & iron labs as above
- Serum erythropoietin
- ESR
- CRP
Chronic/inherited?
- Hemoglobin electrophoresis
- Sickle cell evaluation
Myeloma?
- SPEP & IFE
- UPEP
- Free serum/urine kappa/lambda light chains
- Skeletal survey
Primary marrow process/hematologic malignancy
Less common
- Copper
- Zinc