Difference between revisions of "Pegaspargase (Oncaspar)"
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==Also known as== | ==Also known as== | ||
− | + | *'''Generic names:''' PEG-L-asparaginase, peg-asparginase, pegasparaginase | |
+ | *'''Brand name:''' Oncaspar | ||
==References== | ==References== | ||
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[[Category:Drug index]] | [[Category:Drug index]] | ||
+ | [[Category:Pegylated medications]] | ||
[[Category:Chemotherapy]] | [[Category:Chemotherapy]] | ||
[[Category:Intramuscular medications]] | [[Category:Intramuscular medications]] |
Revision as of 03:47, 17 November 2017
General information
Class/mechanism: Depletes plasma asparagine, selectively killing leukemic cells which are unable to synthesize asparagine due to a lack of asparagine synthetase. The Oncaspar formulation involves L-asparaginase (L-asparagine amidohydrolase) being covalently conjugated to monomethoxypolyethylene glycol (mPEG), increasing its half-life and reducing the risk of hypersensitivity reactions in patients who have history of hypersensitivity to Asparaginase (Elspar).[1][2]
Route: IV, IM
Extravasation: neutral
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]
Diseases for which it is used
- B-cell acute lymphoblastic leukemia
- Extranodal NK/T-cell lymphoma, nasal type
- NK/T-cell lymphoma
- T-cell acute lymphoblastic leukemia
Patient drug information
- Pegaspargase (Oncaspar) patient drug information (Chemocare)[3]
- Pegaspargase (Oncaspar) patient drug information (UpToDate)[4]
History of changes in FDA indication
- 2/1/1994: Initial FDA approval
Also known as
- Generic names: PEG-L-asparaginase, peg-asparginase, pegasparaginase
- Brand name: Oncaspar
References
- Drug index
- Pegylated medications
- Chemotherapy
- Intramuscular medications
- Intravenous medications
- Neutral chemotherapy
- Enzymes
- B-cell acute lymphoblastic leukemia medications
- Extranodal NK/T-cell lymphoma, nasal type medications
- NK/T-cell lymphoma medications
- T-cell acute lymphoblastic leukemia medications
- Drugs FDA approved in 1994