Difference between revisions of "Prostate cancer"

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m (PCA3 links)
m (formatting of headers)
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==Metastatic castrate-resistant disease==
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=Metastatic castrate-resistant disease=
===Cabazitaxel (Jevtana)===
+
==Cabazitaxel (Jevtana)==
====Regimen====
+
===Regimen===
 
*[[Cabazitaxel (Jevtana)]] 25 mg/m2 IV over 1 hour on day 1
 
*[[Cabazitaxel (Jevtana)]] 25 mg/m2 IV over 1 hour on day 1
 
*[[Prednisone (Sterapred)]] 10 mg PO on days 1-21
 
*[[Prednisone (Sterapred)]] 10 mg PO on days 1-21
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*"Antihistamine, corticosteroid (dexamethasone 8 mg or equivalent), and histamine H2-antagonist (except cimetidine)" given at least 30 minutes before cabazitaxel
 
*"Antihistamine, corticosteroid (dexamethasone 8 mg or equivalent), and histamine H2-antagonist (except cimetidine)" given at least 30 minutes before cabazitaxel
  
====References====
+
===References===
 
# de Bono JS, Oudard S, Ozguroglu M, Hansen S, Machiels JP, Kocak I, Gravis G, Bodrogi I, Mackenzie MJ, Shen L, Roessner M, Gupta S, Sartor AO; TROPIC Investigators. Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial. Lancet. 2010 Oct 2;376(9747):1147-54. [http://www.thelancet.com/journals/lancet/article/PIIS0140-6736%2810%2961389-X/fulltext link to original article] '''contains protocol''' [http://www.ncbi.nlm.nih.gov/pubmed/20888992 PubMed]
 
# de Bono JS, Oudard S, Ozguroglu M, Hansen S, Machiels JP, Kocak I, Gravis G, Bodrogi I, Mackenzie MJ, Shen L, Roessner M, Gupta S, Sartor AO; TROPIC Investigators. Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial. Lancet. 2010 Oct 2;376(9747):1147-54. [http://www.thelancet.com/journals/lancet/article/PIIS0140-6736%2810%2961389-X/fulltext link to original article] '''contains protocol''' [http://www.ncbi.nlm.nih.gov/pubmed/20888992 PubMed]
  
===Mitoxantrone (Novantrone)===
+
==Mitoxantrone (Novantrone)==
====Regimen====
+
===Regimen===
 
*[[Mitoxantrone (Novantrone)]] 12 mg/m2 IV over 15-30 minutes on day 1
 
*[[Mitoxantrone (Novantrone)]] 12 mg/m2 IV over 15-30 minutes on day 1
 
*[[Prednisone (Sterapred)]] 10 mg PO on days 1-21
 
*[[Prednisone (Sterapred)]] 10 mg PO on days 1-21
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'''21-day cycles x up to 10 cycles'''
 
'''21-day cycles x up to 10 cycles'''
  
====References====
+
===References===
 
# de Bono JS, Oudard S, Ozguroglu M, Hansen S, Machiels JP, Kocak I, Gravis G, Bodrogi I, Mackenzie MJ, Shen L, Roessner M, Gupta S, Sartor AO; TROPIC Investigators. Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial. Lancet. 2010 Oct 2;376(9747):1147-54. [http://www.thelancet.com/journals/lancet/article/PIIS0140-6736%2810%2961389-X/fulltext link to original article] '''contains protocol''' [http://www.ncbi.nlm.nih.gov/pubmed/20888992 PubMed]
 
# de Bono JS, Oudard S, Ozguroglu M, Hansen S, Machiels JP, Kocak I, Gravis G, Bodrogi I, Mackenzie MJ, Shen L, Roessner M, Gupta S, Sartor AO; TROPIC Investigators. Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial. Lancet. 2010 Oct 2;376(9747):1147-54. [http://www.thelancet.com/journals/lancet/article/PIIS0140-6736%2810%2961389-X/fulltext link to original article] '''contains protocol''' [http://www.ncbi.nlm.nih.gov/pubmed/20888992 PubMed]
  
==Links==
+
=Links=
 
*[http://urology.jhu.edu/prostate/partintables.php Partin tables] to predict pathologic stage based on clinical TNM stage, PSA, and Gleason score
 
*[http://urology.jhu.edu/prostate/partintables.php Partin tables] to predict pathologic stage based on clinical TNM stage, PSA, and Gleason score
 
*[http://www.diagnocure.com/en/products-projects/prostate-cancer/pca3-test-healthcare-practitioners.php PCA3 RNA urine test]
 
*[http://www.diagnocure.com/en/products-projects/prostate-cancer/pca3-test-healthcare-practitioners.php PCA3 RNA urine test]
 
**[http://www.pca3.org/ PCA3.org]
 
**[http://www.pca3.org/ PCA3.org]

Revision as of 04:10, 21 April 2012

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Metastatic castrate-resistant disease

Cabazitaxel (Jevtana)

Regimen

21-day cycles x up to 10 cycles

Supportive medications:

  • "Antihistamine, corticosteroid (dexamethasone 8 mg or equivalent), and histamine H2-antagonist (except cimetidine)" given at least 30 minutes before cabazitaxel

References

  1. de Bono JS, Oudard S, Ozguroglu M, Hansen S, Machiels JP, Kocak I, Gravis G, Bodrogi I, Mackenzie MJ, Shen L, Roessner M, Gupta S, Sartor AO; TROPIC Investigators. Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial. Lancet. 2010 Oct 2;376(9747):1147-54. link to original article contains protocol PubMed

Mitoxantrone (Novantrone)

Regimen

21-day cycles x up to 10 cycles

References

  1. de Bono JS, Oudard S, Ozguroglu M, Hansen S, Machiels JP, Kocak I, Gravis G, Bodrogi I, Mackenzie MJ, Shen L, Roessner M, Gupta S, Sartor AO; TROPIC Investigators. Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial. Lancet. 2010 Oct 2;376(9747):1147-54. link to original article contains protocol PubMed

Links