Difference between revisions of "Pegfilgrastim (Neulasta)"
(Created page with "==General information== Class/mechanism: <ref name="insert">[http://pi.amgen.com/united_states/neulasta/neulasta_pi_hcp_english.pdf Pegfilgrastim (Neulasta) package insert]</ref>...") |
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| + | Also known as G-CSF, granulocyte colony stimulating factor. | ||
| + | |||
==General information== | ==General information== | ||
| − | Class/mechanism: <ref name="insert">[http://pi.amgen.com/united_states/neulasta/neulasta_pi_hcp_english.pdf Pegfilgrastim (Neulasta) package insert]</ref><ref>[http://hemonc.org/docs/packageinsert/pegfilgrastim.pdf Pegfilgrastim (Neulasta) package insert (locally hosted backup)]</ref> | + | Class/mechanism: Recombinant human granulocyte colony-stimulating factor (G-CSF). Binds to cell surface receptors on hematopoietic cells and stimulates proliferation‚ differentiation, and some end-cell functional activation. The Neulasta formulation involves [[Filgrastim (Neupogen)]] being covalently conjugated to monomethoxypolyethylene glycol (mPEG), increasing its half-life.<ref name="insert">[http://pi.amgen.com/united_states/neulasta/neulasta_pi_hcp_english.pdf Pegfilgrastim (Neulasta) package insert]</ref><ref>[http://hemonc.org/docs/packageinsert/pegfilgrastim.pdf Pegfilgrastim (Neulasta) package insert (locally hosted backup)]</ref> |
| − | <br>Route: | + | <br>Route: SC |
| − | <br>Extravasation: | + | <br>Extravasation: n/a |
| + | *"Do not administer Neulasta between 14 days before and 24 hours after administration of cytotoxic chemotherapy."<ref name="insert"></ref> | ||
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as [http://www.thomsonhc.com/home/dispatch Micromedex], [http://online.lexi.com/ Lexicomp], [http://www.utdol.com/online/content/search.do UpToDate (courtesy of Lexicomp)], or the package insert<ref name="insert"></ref>. | For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as [http://www.thomsonhc.com/home/dispatch Micromedex], [http://online.lexi.com/ Lexicomp], [http://www.utdol.com/online/content/search.do UpToDate (courtesy of Lexicomp)], or the package insert<ref name="insert"></ref>. | ||
Revision as of 16:50, 24 February 2012
Also known as G-CSF, granulocyte colony stimulating factor.
General information
Class/mechanism: Recombinant human granulocyte colony-stimulating factor (G-CSF). Binds to cell surface receptors on hematopoietic cells and stimulates proliferation‚ differentiation, and some end-cell functional activation. The Neulasta formulation involves Filgrastim (Neupogen) being covalently conjugated to monomethoxypolyethylene glycol (mPEG), increasing its half-life.[1][2]
Route: SC
Extravasation: n/a
- "Do not administer Neulasta between 14 days before and 24 hours after administration of cytotoxic chemotherapy."[1]
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the package insert[1].
Patient drug information
- Pegfilgrastim (Neulasta) patient drug information (Chemocare)[3]
- Pegfilgrastim (Neulasta) patient drug information (UpToDate)[4]