Difference between revisions of "Meningioma"
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=Unresectable, all lines of therapy= | =Unresectable, all lines of therapy= | ||
==Placebo== | ==Placebo== | ||
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===Regimen=== | ===Regimen=== | ||
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''No active antineoplastic treatment.'' | ''No active antineoplastic treatment.'' | ||
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===References=== | ===References=== | ||
# '''SWOG S9005:''' Ji Y, Rankin C, Grunberg S, Sherrod AE, Ahmadi J, Townsend JJ, Feun LG, Fredericks RK, Russell CA, Kabbinavar FF, Stelzer KJ, Schott A, Verschraegen C. Double-blind phase III randomized trial of the antiprogestin agent mifepristone in the treatment of unresectable meningioma: SWOG S9005. J Clin Oncol. 2015 Dec 1;33(34):4093-8. Epub 2015 Nov 2. [https://doi.org/10.1200/JCO.2015.61.6490 link to original article] [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4669593/ link to PMC article] [https://pubmed.ncbi.nlm.nih.gov/26527781 PubMed] NCT03015701 | # '''SWOG S9005:''' Ji Y, Rankin C, Grunberg S, Sherrod AE, Ahmadi J, Townsend JJ, Feun LG, Fredericks RK, Russell CA, Kabbinavar FF, Stelzer KJ, Schott A, Verschraegen C. Double-blind phase III randomized trial of the antiprogestin agent mifepristone in the treatment of unresectable meningioma: SWOG S9005. J Clin Oncol. 2015 Dec 1;33(34):4093-8. Epub 2015 Nov 2. [https://doi.org/10.1200/JCO.2015.61.6490 link to original article] [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4669593/ link to PMC article] [https://pubmed.ncbi.nlm.nih.gov/26527781 PubMed] NCT03015701 | ||
Revision as of 17:20, 28 February 2023
| Section editor | |
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Seema Nagpal, MD Stanford University Palo Alto, CA |
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Guidelines
EANO
NCCN
Unresectable, all lines of therapy
Placebo
Regimen
| Study | Years of enrollment | Evidence | Comparator | Comparative Efficacy |
|---|---|---|---|---|
| Ji et al. 2015 (SWOG S9005) | 1992-1998 | Phase 3 (C) | Mifepristone | Did not meet primary endpoint of FFS |
No active antineoplastic treatment.
References
- SWOG S9005: Ji Y, Rankin C, Grunberg S, Sherrod AE, Ahmadi J, Townsend JJ, Feun LG, Fredericks RK, Russell CA, Kabbinavar FF, Stelzer KJ, Schott A, Verschraegen C. Double-blind phase III randomized trial of the antiprogestin agent mifepristone in the treatment of unresectable meningioma: SWOG S9005. J Clin Oncol. 2015 Dec 1;33(34):4093-8. Epub 2015 Nov 2. link to original article link to PMC article PubMed NCT03015701