Meningioma

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Seema Nagpal, MD
Stanford University
Palo Alto, CA
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Guidelines

EANO

NCCN

Unresectable, all lines of therapy

Placebo

Regimen

Study Years of enrollment Evidence Comparator Comparative Efficacy
Ji et al. 2015 (SWOG S9005) 1992-1998 Phase 3 (C) Mifepristone Did not meet primary endpoint of FFS

No active antineoplastic treatment.

References

  1. SWOG S9005: Ji Y, Rankin C, Grunberg S, Sherrod AE, Ahmadi J, Townsend JJ, Feun LG, Fredericks RK, Russell CA, Kabbinavar FF, Stelzer KJ, Schott A, Verschraegen C. Double-blind phase III randomized trial of the antiprogestin agent mifepristone in the treatment of unresectable meningioma: SWOG S9005. J Clin Oncol. 2015 Dec 1;33(34):4093-8. Epub 2015 Nov 2. link to original article link to PMC article PubMed NCT03015701