Difference between revisions of "Fotemustine (Muphoran)"
Jump to navigation
Jump to search
m |
Warner-admin (talk | contribs) m (Text replacement - "[[Category:Hodgkin lymphoma " to "[[Category:Classical Hodgkin lymphoma ") |
||
Line 17: | Line 17: | ||
[[Category:Diffuse large B-cell lymphoma medications]] | [[Category:Diffuse large B-cell lymphoma medications]] | ||
− | [[Category:Hodgkin lymphoma medications]] | + | [[Category:Classical Hodgkin lymphoma medications]] |
[[Category:Melanoma medications]] | [[Category:Melanoma medications]] | ||
[[Category:Uveal melanoma medications]] | [[Category:Uveal melanoma medications]] | ||
[[Category:EMA approved drugs]] | [[Category:EMA approved drugs]] |
Revision as of 14:15, 9 June 2023
Mechanism of action
From the NCI Drug Dictionary: A chloroethylating nitrosourea with antineoplastic activity. Fotemustine alkylates guanine by forming chloroethyl adducts at the 6 position of guanine, resulting in N1-guanine and N3-cytosine cross linkages, inhibition of DNA synthesis, cell cycle arrest, and finally apoptosis. This agent is lipophilic and crosses the blood-brain barrier.
Diseases for which it is used
Also known as
- Brand names: Muphoran, Mustophoran