Difference between revisions of "Pegfilgrastim (Neulasta)"
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==General information== | ==General information== | ||
| − | Class/mechanism: Recombinant human granulocyte colony-stimulating factor (G-CSF). Binds to cell surface receptors on hematopoietic cells and stimulates proliferation‚ differentiation, and some end-cell functional activation. The Neulasta formulation involves [[Filgrastim (Neupogen)]] being covalently conjugated to monomethoxypolyethylene glycol (mPEG), increasing its half-life.<ref name="insert">[http://pi.amgen.com/united_states/neulasta/neulasta_pi_hcp_english.pdf Pegfilgrastim (Neulasta) package insert]</ref><ref>[ | + | Class/mechanism: Recombinant human granulocyte colony-stimulating factor (G-CSF). Binds to cell surface receptors on hematopoietic cells and stimulates proliferation‚ differentiation, and some end-cell functional activation. The Neulasta formulation involves [[Filgrastim (Neupogen)]] being covalently conjugated to monomethoxypolyethylene glycol (mPEG), increasing its half-life.<ref name="insert">[http://pi.amgen.com/united_states/neulasta/neulasta_pi_hcp_english.pdf Pegfilgrastim (Neulasta) package insert]</ref><ref>[[Media:Pegfilgrastim.pdf| Pegfilgrastim (Neulasta) package insert (locally hosted backup)]]</ref><ref>[https://www.neulasta.com/ Neulasta manufacturer's website]</ref> |
<br>Route: SC | <br>Route: SC | ||
<br>Extravasation: n/a | <br>Extravasation: n/a | ||
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==Patient drug information== | ==Patient drug information== | ||
| + | *[http://pi.amgen.com/united_states/neulasta/neulasta_pi_hcp_english.pdf Pegfilgrastim (Neulasta) package insert]<ref name="insert"></ref> | ||
*[http://chemocare.com/bio/pegfilgrastim.asp Pegfilgrastim (Neulasta) patient drug information (Chemocare)]<ref>[http://chemocare.com/bio/pegfilgrastim.asp Pegfilgrastim (Neulasta) patient drug information (Chemocare)]</ref> | *[http://chemocare.com/bio/pegfilgrastim.asp Pegfilgrastim (Neulasta) patient drug information (Chemocare)]<ref>[http://chemocare.com/bio/pegfilgrastim.asp Pegfilgrastim (Neulasta) patient drug information (Chemocare)]</ref> | ||
*[http://www.uptodate.com/contents/pegfilgrastim-patient-drug-information Pegfilgrastim (Neulasta) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/pegfilgrastim-patient-drug-information Pegfilgrastim (Neulasta) patient drug information (UpToDate)]</ref> | *[http://www.uptodate.com/contents/pegfilgrastim-patient-drug-information Pegfilgrastim (Neulasta) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/pegfilgrastim-patient-drug-information Pegfilgrastim (Neulasta) patient drug information (UpToDate)]</ref> | ||
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| + | ==Also known as== | ||
| + | pegylated GCSF, G-CSF, or granulocyte colony stimulating factor. | ||
==References== | ==References== | ||
Revision as of 16:04, 30 April 2017
General information
Class/mechanism: Recombinant human granulocyte colony-stimulating factor (G-CSF). Binds to cell surface receptors on hematopoietic cells and stimulates proliferation‚ differentiation, and some end-cell functional activation. The Neulasta formulation involves Filgrastim (Neupogen) being covalently conjugated to monomethoxypolyethylene glycol (mPEG), increasing its half-life.[1][2][3]
Route: SC
Extravasation: n/a
- "Do not administer Neulasta between 14 days before and 24 hours after administration of cytotoxic chemotherapy."[1]
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]
Patient drug information
- Pegfilgrastim (Neulasta) package insert[1]
- Pegfilgrastim (Neulasta) patient drug information (Chemocare)[4]
- Pegfilgrastim (Neulasta) patient drug information (UpToDate)[5]
Also known as
pegylated GCSF, G-CSF, or granulocyte colony stimulating factor.