Difference between revisions of "Fluorouracil (5-FU)"

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Also known as Adrucil.
 
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==General information==
 
==General information==
 
Class/mechanism: Pyrimidine analog, antimetabolite, inhibitor of thymidylate synthase.  Metabolized to 5-fluoro-2'-deoxyuridine monophosphate (FdUMP) and 5-fluorouridine triphosphate (FUTP).  FdUMP inhibits DNA synthesis by binding to thymidylate synthase and inhibiting production of thymidylate; FUTP interferes with RNA processing when it is mistakenly incorporated in place of uridine triphosphate (UTP).<ref name="insert">[http://patient.cancerconsultants.com/druginserts/Fluorouracil.pdf Fluorouracil (5-FU) package insert]</ref><ref>[http://hemonc.org/docs/packageinsert/fluorouracil.pdf Fluorouracil (5-FU) package insert (locally hosted backup)]</ref> <ref>[http://en.wikipedia.org/wiki/Fluorouracil#Interactive_pathway_map 5-FU pathway]</ref>.
 
Class/mechanism: Pyrimidine analog, antimetabolite, inhibitor of thymidylate synthase.  Metabolized to 5-fluoro-2'-deoxyuridine monophosphate (FdUMP) and 5-fluorouridine triphosphate (FUTP).  FdUMP inhibits DNA synthesis by binding to thymidylate synthase and inhibiting production of thymidylate; FUTP interferes with RNA processing when it is mistakenly incorporated in place of uridine triphosphate (UTP).<ref name="insert">[http://patient.cancerconsultants.com/druginserts/Fluorouracil.pdf Fluorouracil (5-FU) package insert]</ref><ref>[http://hemonc.org/docs/packageinsert/fluorouracil.pdf Fluorouracil (5-FU) package insert (locally hosted backup)]</ref> <ref>[http://en.wikipedia.org/wiki/Fluorouracil#Interactive_pathway_map 5-FU pathway]</ref>.
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*[http://chemocare.com/bio/fluorouracil.asp Fluorouracil (5-FU) patient drug information (Chemocare)]<ref>[http://chemocare.com/bio/fluorouracil.asp Fluorouracil (5-FU) patient drug information (Chemocare)]</ref>
 
*[http://chemocare.com/bio/fluorouracil.asp Fluorouracil (5-FU) patient drug information (Chemocare)]<ref>[http://chemocare.com/bio/fluorouracil.asp Fluorouracil (5-FU) patient drug information (Chemocare)]</ref>
 
*[http://www.uptodate.com/contents/fluorouracil-patient-drug-information Fluorouracil (5-FU) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/fluorouracil-patient-drug-information Fluorouracil (5-FU) patient drug information (UpToDate)]</ref>
 
*[http://www.uptodate.com/contents/fluorouracil-patient-drug-information Fluorouracil (5-FU) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/fluorouracil-patient-drug-information Fluorouracil (5-FU) patient drug information (UpToDate)]</ref>
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==History of changes in FDA indication==
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* 4/25/1962: Initial FDA approval
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==Also known as==
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{| border="1" style="text-align:center;"
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!colspan="8" align="center" style="background-color:#0066FF"| '''Synonyms'''
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|-
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|5 Fluorouracil
 +
|5 FU
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|5 FU Kyowa Hakko
 +
|5 FU Meiji
 +
|5 FU Orca
 +
|5-fluoracilo
 +
|5-fluorouracilo
 +
|5-fluorouracyl-knoll
 +
|-
 +
|5-FU Kyowa
 +
|5-FU Medac
 +
|Accusite
 +
|Actino Hermal
 +
|Adrucil
 +
|Arumel
 +
|Benton
 +
|Biofur
 +
|-
 +
|Carac
 +
|Carebin
 +
|Carzonal
 +
|Cinco-FU
 +
|Cinkef-U
 +
|Curacil
 +
|Effcil
 +
|Efudex
 +
|-
 +
|Efurix
 +
|Ezadex
 +
|Fauldfluor
 +
|Fivocil
 +
|Fivoflu
 +
|Flacule
 +
|Flonida
 +
|Florac
 +
|-
 +
|Flourouracil
 +
|Fluhomer
 +
|Fluolex
 +
|Fluor-Uracil
 +
|Fluoro-Uracile ICN
 +
|Fluoro-Uracil ICN
 +
|Fluoroplex
 +
|Fluorouracil
 +
|-
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|Fluorouracil-GRY
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|Fluorouracil 5 FU
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|Fluorouracil Abic
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|Fluorouracil Bigmar
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|Fluorouracil CO
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|Fluorouracil DBL
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|Fluorouracile
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|Fluorouracile Dakota
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|-
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|Fluorouracil Faulding
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|Fluorouracil Mayne
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|Fluorouracil Mayne Pharma ( BEN )
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|Fluorouracilo
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|Fluorouracilo Filaxis
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|Fluorouracilo Martian
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|Fluorouracilo Rontag
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|Fluorouracil Pliva
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|-
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|Fluorouracil Roche
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|Fluorouracil Sanofi-Synthelabo
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|Fluorouracil Sodium
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|Fluorouracil Till
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|Fluorourcil
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|Fluoruracilo
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|Fluoxan
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|Flurablastin
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|-
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|Flurac
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|Fluracedyl
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|Fluracil
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|Fluroblastin
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|Fluroblastine
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|Ftoruracil
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|Ftouracil
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|FU
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|-
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|FU Kyorin
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|FU MI TE
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|FU Schering
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|Haemato-FU
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|Ifacil
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|Kang Ning
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|Kecimeton Tatumi
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|Killit
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|-
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|LA FU
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|Lunachol DS Sawai
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|Lunachol Yoshitomi
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|Lunapon
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|Natira U
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|Neofluor
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|O Fluor
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|Oncofu
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|-
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|Onkofluor
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|Pentafu
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|Pharmauracil
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|Phthoruracil
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|Phtoruracil
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|Ribofluor
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|Rotianin
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|Sanc F D
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|-
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|Satelol
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|Seco Uracil
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|Tecflu
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|Timadin
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|Timadin Dry
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|Trav Fluorouracil
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|Triosules
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|Uflahex
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|-
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|Ulosagen
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|Ulup Maruko
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|Ulup Mitsubishi
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|Uraciflor
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|Utoral
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|Vaflu
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|Vafu
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|Zhongren FU AN
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|-
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|}
  
 
==References==
 
==References==
 
<references/>
 
<references/>
  
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[[Category:Drug index]]
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[[Category:Chemotherapy]]
 
[[Category:Irritant chemotherapy]]
 
[[Category:Irritant chemotherapy]]
  
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[[Category:Prostate cancer medications]]
 
[[Category:Prostate cancer medications]]
 
[[Category:Rectal cancer medications]]
 
[[Category:Rectal cancer medications]]
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[[Category:Drugs FDA approved in 1962]]

Revision as of 02:50, 4 November 2014

General information

Class/mechanism: Pyrimidine analog, antimetabolite, inhibitor of thymidylate synthase. Metabolized to 5-fluoro-2'-deoxyuridine monophosphate (FdUMP) and 5-fluorouridine triphosphate (FUTP). FdUMP inhibits DNA synthesis by binding to thymidylate synthase and inhibiting production of thymidylate; FUTP interferes with RNA processing when it is mistakenly incorporated in place of uridine triphosphate (UTP).[1][2] [3].
Route: IV
Extravasation: irritant

For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]

Diseases for which it is used

Patient drug information

History of changes in FDA indication

  • 4/25/1962: Initial FDA approval

Also known as

Synonyms
5 Fluorouracil 5 FU 5 FU Kyowa Hakko 5 FU Meiji 5 FU Orca 5-fluoracilo 5-fluorouracilo 5-fluorouracyl-knoll
5-FU Kyowa 5-FU Medac Accusite Actino Hermal Adrucil Arumel Benton Biofur
Carac Carebin Carzonal Cinco-FU Cinkef-U Curacil Effcil Efudex
Efurix Ezadex Fauldfluor Fivocil Fivoflu Flacule Flonida Florac
Flourouracil Fluhomer Fluolex Fluor-Uracil Fluoro-Uracile ICN Fluoro-Uracil ICN Fluoroplex Fluorouracil
Fluorouracil-GRY Fluorouracil 5 FU Fluorouracil Abic Fluorouracil Bigmar Fluorouracil CO Fluorouracil DBL Fluorouracile Fluorouracile Dakota
Fluorouracil Faulding Fluorouracil Mayne Fluorouracil Mayne Pharma ( BEN ) Fluorouracilo Fluorouracilo Filaxis Fluorouracilo Martian Fluorouracilo Rontag Fluorouracil Pliva
Fluorouracil Roche Fluorouracil Sanofi-Synthelabo Fluorouracil Sodium Fluorouracil Till Fluorourcil Fluoruracilo Fluoxan Flurablastin
Flurac Fluracedyl Fluracil Fluroblastin Fluroblastine Ftoruracil Ftouracil FU
FU Kyorin FU MI TE FU Schering Haemato-FU Ifacil Kang Ning Kecimeton Tatumi Killit
LA FU Lunachol DS Sawai Lunachol Yoshitomi Lunapon Natira U Neofluor O Fluor Oncofu
Onkofluor Pentafu Pharmauracil Phthoruracil Phtoruracil Ribofluor Rotianin Sanc F D
Satelol Seco Uracil Tecflu Timadin Timadin Dry Trav Fluorouracil Triosules Uflahex
Ulosagen Ulup Maruko Ulup Mitsubishi Uraciflor Utoral Vaflu Vafu Zhongren FU AN

References

  1. ↑ 1.0 1.1 Fluorouracil (5-FU) package insert
  2. ↑ Fluorouracil (5-FU) package insert (locally hosted backup)
  3. ↑ 5-FU pathway
  4. ↑ Fluorouracil (5-FU) patient drug information (Chemocare)
  5. ↑ Fluorouracil (5-FU) patient drug information (UpToDate)
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