Difference between revisions of "Epithelioid sarcoma"
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!style="width: 33%"|[[Levels_of_Evidence#Evidence|Evidence]] | !style="width: 33%"|[[Levels_of_Evidence#Evidence|Evidence]] | ||
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| − | |[https://doi.org/10. | + | |[https://doi.org/10.1016/s1470-2045(20)30451-4 Gounder et al. 2020 (EZH-202)] |
| − | | | + | |2015-2017 |
| style="background-color:#91cf61" |Phase II (RT) | | style="background-color:#91cf61" |Phase II (RT) | ||
|- | |- | ||
|} | |} | ||
| − | + | ====Biomarker eligiblity criteria==== | |
| + | One or both of the following: | ||
| + | *Loss of INI1 expression by IHC | ||
| + | *Biallelic SMARCB1 alterations | ||
====Targeted therapy==== | ====Targeted therapy==== | ||
*[[Tazemetostat (Tazverik)]] 800 mg PO twice per day | *[[Tazemetostat (Tazverik)]] 800 mg PO twice per day | ||
| − | ''' | + | '''28-day cycles''' |
===References=== | ===References=== | ||
| − | # '''Abstract:''' Mrinal M. Gounder, Silvia Stacchiotti, Patrick Schöffski, Steven Attia, Antoine Italiano, Robin Jones, George D. Demetri, Stephen Blakemore, Alicia Clawson, Scott Daigle, Scott Ribich, Maria Roche, Jill Rodstrom, Peter T.C. Ho, and Gregory Michael Cote. Phase 2 multicenter study of the EZH2 inhibitor tazemetostat in adults with INI1 negative epithelioid sarcoma (NCT02601950). Journal of Clinical Oncology 2017 35:15_suppl, 11058-11058. [https://doi.org/10.1200/JCO.2017.35.15_suppl.11058 link to abstract] [https://clinicaltrials.gov/ct2/show/NCT02601950 CT.gov] | + | <!-- # '''Abstract:''' Mrinal M. Gounder, Silvia Stacchiotti, Patrick Schöffski, Steven Attia, Antoine Italiano, Robin Jones, George D. Demetri, Stephen Blakemore, Alicia Clawson, Scott Daigle, Scott Ribich, Maria Roche, Jill Rodstrom, Peter T.C. Ho, and Gregory Michael Cote. Phase 2 multicenter study of the EZH2 inhibitor tazemetostat in adults with INI1 negative epithelioid sarcoma (NCT02601950). Journal of Clinical Oncology 2017 35:15_suppl, 11058-11058. [https://doi.org/10.1200/JCO.2017.35.15_suppl.11058 link to abstract] [https://clinicaltrials.gov/ct2/show/NCT02601950 CT.gov] --> |
| + | # '''EZH-202:''' Gounder M, Schöffski P, Jones RL, Agulnik M, Cote GM, Villalobos VM, Attia S, Chugh R, Chen TW, Jahan T, Loggers ET, Gupta A, Italiano A, Demetri GD, Ratan R, Davis LE, Mir O, Dileo P, Van Tine BA, Pressey JG, Lingaraj T, Rajarethinam A, Sierra L, Agarwal S, Stacchiotti S. Tazemetostat in advanced epithelioid sarcoma with loss of INI1/SMARCB1: an international, open-label, phase 2 basket study. Lancet Oncol. 2020 Nov;21(11):1423-1432. Epub 2020 Oct 6. [https://doi.org/10.1016/s1470-2045(20)30451-4 link to original article] '''contains protocol''' [https://pubmed.ncbi.nlm.nih.gov/33035459/ PubMed] NCT02601950 | ||
[[Category:Epithelioid sarcoma regimens]] | [[Category:Epithelioid sarcoma regimens]] | ||
Revision as of 14:16, 6 March 2021
| Section editor | |
|---|---|
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Elizabeth J. Davis, MD Vanderbilt University Nashville, TN  ejdavis25
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Note: these are regimens tested in subtype-specific populations, please see the main soft tissue sarcoma page for other regimens.
1 regimens on this page
1 variants on this page
|
All lines of therapy
Tazemetostat monotherapy
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Regimen
| FDA-recommended dose |
| Study | Years of enrollment | Evidence |
|---|---|---|
| Gounder et al. 2020 (EZH-202) | 2015-2017 | Phase II (RT) |
Biomarker eligiblity criteria
One or both of the following:
- Loss of INI1 expression by IHC
- Biallelic SMARCB1 alterations
Targeted therapy
- Tazemetostat (Tazverik) 800 mg PO twice per day
28-day cycles
References
- EZH-202: Gounder M, Schöffski P, Jones RL, Agulnik M, Cote GM, Villalobos VM, Attia S, Chugh R, Chen TW, Jahan T, Loggers ET, Gupta A, Italiano A, Demetri GD, Ratan R, Davis LE, Mir O, Dileo P, Van Tine BA, Pressey JG, Lingaraj T, Rajarethinam A, Sierra L, Agarwal S, Stacchiotti S. Tazemetostat in advanced epithelioid sarcoma with loss of INI1/SMARCB1: an international, open-label, phase 2 basket study. Lancet Oncol. 2020 Nov;21(11):1423-1432. Epub 2020 Oct 6. link to original article contains protocol PubMed NCT02601950