Difference between revisions of "Mitomycin (Mutamycin)"
Jump to navigation
Jump to search
m |
|||
| Line 1: | Line 1: | ||
| − | |||
| − | |||
==General information== | ==General information== | ||
Class/mechanism: Antibiotic oncologic isolated from Streptomyces caespitosus; inhibits DNA synthesis and induces crosslinking. At higher concentrations, can also inhibit RNA and protein synthesis.<ref name="insert">[http://patient.cancerconsultants.com/druginserts/Mitomycin.pdf Mitomycin (Mutamycin) package insert]</ref><ref>[http://hemonc.org/docs/packageinsert/mitomycin.pdf Mitomycin (Mutamycin) package insert (locally hosted backup)]</ref> | Class/mechanism: Antibiotic oncologic isolated from Streptomyces caespitosus; inhibits DNA synthesis and induces crosslinking. At higher concentrations, can also inhibit RNA and protein synthesis.<ref name="insert">[http://patient.cancerconsultants.com/druginserts/Mitomycin.pdf Mitomycin (Mutamycin) package insert]</ref><ref>[http://hemonc.org/docs/packageinsert/mitomycin.pdf Mitomycin (Mutamycin) package insert (locally hosted backup)]</ref> | ||
| Line 18: | Line 16: | ||
*[http://chemocare.com/bio/mitomycin.asp Mitomycin (Mutamycin) patient drug information (Chemocare)]<ref>[http://chemocare.com/bio/mitomycin.asp Mitomycin (Mutamycin) patient drug information (Chemocare)]</ref> | *[http://chemocare.com/bio/mitomycin.asp Mitomycin (Mutamycin) patient drug information (Chemocare)]<ref>[http://chemocare.com/bio/mitomycin.asp Mitomycin (Mutamycin) patient drug information (Chemocare)]</ref> | ||
*[http://www.uptodate.com/contents/mitomycin-patient-drug-information Mitomycin (Mutamycin) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/mitomycin-patient-drug-information Mitomycin (Mutamycin) patient drug information (UpToDate)]</ref> | *[http://www.uptodate.com/contents/mitomycin-patient-drug-information Mitomycin (Mutamycin) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/mitomycin-patient-drug-information Mitomycin (Mutamycin) patient drug information (UpToDate)]</ref> | ||
| + | |||
| + | ==History of changes in FDA indication== | ||
| + | *8/24/1981: Initial FDA approval | ||
| + | |||
| + | ==Also known as== | ||
| + | Mitomycin-C, MTC, Mitozytrex | ||
==References== | ==References== | ||
<references/> | <references/> | ||
| + | |||
| + | [[Category:Chemotherapy]] | ||
| + | [[Category:Vesicant chemotherapy]] | ||
| + | |||
| + | [[Category:DNA synthesis inhibitors]] | ||
| + | |||
| + | [[Category:Anal cancer medications]] | ||
| + | [[Category:Bladder cancer medications]] | ||
| + | [[Category:Cervical cancer medications]] | ||
| + | [[Category:Esophageal cancer medications]] | ||
| + | [[Category:Hepatobiliary cancer medications]] | ||
| + | |||
| + | [[Category:Drugs FDA approved in 1981]] | ||
Revision as of 18:43, 19 September 2014
General information
Class/mechanism: Antibiotic oncologic isolated from Streptomyces caespitosus; inhibits DNA synthesis and induces crosslinking. At higher concentrations, can also inhibit RNA and protein synthesis.[1][2]
Route: IV
Extravasation: vesicant
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]
Diseases for which it is used
Patient drug information
- Mitomycin (Mutamycin) patient drug information (Chemocare)[3]
- Mitomycin (Mutamycin) patient drug information (UpToDate)[4]
History of changes in FDA indication
- 8/24/1981: Initial FDA approval
Also known as
Mitomycin-C, MTC, Mitozytrex