Difference between revisions of "Breast cancer BRCA1 & BRCA2 genetic testing"
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=Criteria for BRCA1/BRCA2 genetic testing= | =Criteria for BRCA1/BRCA2 genetic testing= | ||
Revision as of 13:48, 25 January 2018
Carboplatin & Paclitaxel (CP)
CP: Carboplatin & Paclitaxel
Regimen
| Study | Dates of enrollment | Evidence | Comparator | Comparative Efficacy |
|---|---|---|---|---|
| Forde et al. 2022 (CheckMate 816) | 2017-2019 | Phase 3 (C) | 1a. CP & Nivolumab 1b. CVb & Nivolumab 1c. DC & Nivolumab |
Inferior EFS |
Note: there were additional comparator options depending on histology; see the respective histology-specific pages for more details. This study was conducted in the United States. The reason for the study was that an unanswered question at the time was whether adding an immune checkpoint inhibitor would improve outcomes.
Biomarker eligibility criteria
- CheckMate 816: No sensitizing EGFR or ALK mutations
Chemotherapy
- Carboplatin (Paraplatin) AUC 5 or 6 IV once on day 1
- Paclitaxel (Taxol) 175 or 200 mg/m2 IV once on day 1
21-day cycle for 3 cycles
Subsequent treatment
References
- CheckMate 816: Forde PM, Spicer J, Lu S, Provencio M, Mitsudomi T, Awad MM, Felip E, Broderick SR, Brahmer JR, Swanson SJ, Kerr K, Wang C, Ciuleanu TE, Saylors GB, Tanaka F, Ito H, Chen KN, Liberman M, Vokes EE, Taube JM, Dorange C, Cai J, Fiore J, Jarkowski A, Balli D, Sausen M, Pandya D, Calvet CY, Girard N; CheckMate 816 Investigators. Neoadjuvant Nivolumab plus Chemotherapy in Resectable Lung Cancer. N Engl J Med. 2022 May 26;386(21):1973-1985. Epub 2022 Apr 11. link to original article contains dosing details in manuscript PubMed NCT02998528
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Use of this site is subject to you reading and agreeing with the terms set forth in the disclaimer. If this is your first time visiting, we suggest you read the tutorial.
Criteria for BRCA1/BRCA2 genetic testing
This is from a clinical trial protocol and is similar to, but not identical to, the NCCN breast cancer familiar risk assessment guidelines.[1] Additional resources can be found at the links below.[2][3]
- Breast cancer diagnosed ≤45 years old
- Diagnosed at age ≤50 years old with:
- first, second, or third-degree blood relative with breast cancer diagnosis ≤50 years old
- and/or epithelial ovarian or fallopian peritoneal cancer at any age
- Diagnosed at age <60 years old with a triple negative breast cancer
- Two breast primaries--that is, bilateral disease or two or more clearly separate ipsilateral primary tumors--when first breast cancer diagnosis occurred prior to age 50
- Personal history of epithelial ovarian, fallopian tube, or primary peritoneal cancer
- Diagnosed at any age with ≥2 first, second, or third-degree relatives with breast and/or epithelial ovarian, fallopian tube, or primary peritoneal cancer at any age
- First or second-degree relative of anybody known to carry a harmful BRCA1 or BRCA2 mutation
- Ashkenazi Jewish descent
- Male breast cancer
- First, second, or third-degree male relative with breast cancer