Difference between revisions of "Hydroxyurea (Hydrea)"
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==Diseases for which it is used== | ==Diseases for which it is used== | ||
*[[Acute myeloid leukemia]] | *[[Acute myeloid leukemia]] | ||
− | *[[ | + | *[[Acute promyelocytic leukemia]] |
*[[Cervical cancer]] | *[[Cervical cancer]] | ||
*[[Essential thrombocythemia]] | *[[Essential thrombocythemia]] | ||
+ | *[[Glioblastoma]] | ||
*[[Head and neck cancer]] | *[[Head and neck cancer]] | ||
*[[Hypereosinophilic syndrome]] | *[[Hypereosinophilic syndrome]] | ||
+ | *[[Myelofibrosis]] | ||
*[[Polycythemia vera]] | *[[Polycythemia vera]] | ||
*[[Sickle cell anemia]] | *[[Sickle cell anemia]] | ||
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==Also known as== | ==Also known as== | ||
− | + | *'''Generic names:''' dhnp, hidroxiurea, hydroxycarbam, hydroxycarbamid, hydroxycarbamide | |
− | + | *'''Brand names:''' Biosupressin, Cytodrox, Droxia, Droxiurea, Durea, Hidrea, Hondrea, Hydab, Hydrea, Hydrine, Hydrourea, Hytas, Litalir, Myelostat, Mylocel, Neodrea, Onco Carbide, Siklos, Syrea, Ureax | |
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==References== | ==References== | ||
<references/> | <references/> | ||
[[Category:Drug index]] | [[Category:Drug index]] | ||
− | [[Category: | + | [[Category:Oral medications]] |
+ | |||
[[Category:DNA synthesis inhibitors]] | [[Category:DNA synthesis inhibitors]] | ||
[[Category:Acute myeloid leukemia medications]] | [[Category:Acute myeloid leukemia medications]] | ||
− | [[Category: | + | [[Category:Acute promyelocytic leukemia medications]] |
[[Category:Cervical cancer medications]] | [[Category:Cervical cancer medications]] | ||
[[Category:Essential thrombocythemia medications]] | [[Category:Essential thrombocythemia medications]] | ||
+ | [[Category:Glioblastoma medications]] | ||
[[Category:Head and neck cancer medications]] | [[Category:Head and neck cancer medications]] | ||
[[Category:Hypereosinophilic syndrome medications]] | [[Category:Hypereosinophilic syndrome medications]] | ||
+ | [[Category:Myelofibrosis medications]] | ||
[[Category:Polycythemia vera medications]] | [[Category:Polycythemia vera medications]] | ||
[[Category:Sickle cell anemia medications]] | [[Category:Sickle cell anemia medications]] |
Revision as of 03:03, 28 January 2018
General information
Class/mechanism: Exact mechanism unclear, but data suggests that hydroxyurea inhibits DNA synthesis by inhibiting ribonucleotide reductase, which inhibits cancer cell growth. May sensitize tumors to radiation by keeping cells in the G1 phase of the cell cycle, where they are most vulnerable to radiation, and/or by interfering with DNA repair processes. Does not appear to affect RNA and protein synthesis.[1][2]
Route: PO
Extravasation: n/a
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]
Diseases for which it is used
- Acute myeloid leukemia
- Acute promyelocytic leukemia
- Cervical cancer
- Essential thrombocythemia
- Glioblastoma
- Head and neck cancer
- Hypereosinophilic syndrome
- Myelofibrosis
- Polycythemia vera
- Sickle cell anemia
Patient drug information
- Brief patient counseling information can be found in the Hydroxyurea (Hydrea) package insert[1]
- Hydroxyurea (Hydrea) patient drug information (Chemocare)[3]
- Hydroxyurea (Hydrea) patient drug information (UpToDate)[4]
History of changes in FDA indication
- 12/7/1967: Initial FDA approval
- 12/21/2017: Granted regular FDA approval (as Siklos) to reduce the frequency of painful crises and the need for blood transfusions in pediatric patients from 2 years of age and older with sickle cell anemia with recurrent moderate to severe painful crises.
Also known as
- Generic names: dhnp, hidroxiurea, hydroxycarbam, hydroxycarbamid, hydroxycarbamide
- Brand names: Biosupressin, Cytodrox, Droxia, Droxiurea, Durea, Hidrea, Hondrea, Hydab, Hydrea, Hydrine, Hydrourea, Hytas, Litalir, Myelostat, Mylocel, Neodrea, Onco Carbide, Siklos, Syrea, Ureax
References
- Drug index
- Oral medications
- DNA synthesis inhibitors
- Acute myeloid leukemia medications
- Acute promyelocytic leukemia medications
- Cervical cancer medications
- Essential thrombocythemia medications
- Glioblastoma medications
- Head and neck cancer medications
- Hypereosinophilic syndrome medications
- Myelofibrosis medications
- Polycythemia vera medications
- Sickle cell anemia medications
- Drugs FDA approved in 1967
- WHO Essential Cancer Medicine